Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function

Cruz-Correa, Marcia Roxana; Sala, Ana Cecilia; Cintrón, Beatriz; Hernández, Jessica; Olivera, Myrta; Cora, Adrian; Moore, Constance M.; Luciano, Carlos A.; Soto-Salgado, Marievelisse; Giardiello, Francis M.; Hooper, Stephen R.

doi:10.1186/s13053-020-0135-3

Hereditary Cancer in Clinical Practice

Table 2 Comparison of the FAP and control groups on the neurocognitive functions

From: Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function

Measure	FAP group (n = 26)		Control group (n = 25)		p-value*	Simple LRM (coefficients)	p-value	Adjusted multivariate LRM** (coefficients)	p-value	Adjusted multivariate LRM*** (coefficients)	p-value
Measure	Mean	SD	Mean	SD	p-value*	Simple LRM (coefficients)	p-value	Adjusted multivariate LRM** (coefficients)	p-value	Adjusted multivariate LRM*** (coefficients)	p-value
TONI-4 IQ	90.5	5.6	95.6	6.8	0.005	−5.1	0.005	−5.2	0.005	−5.0	0.008
Batería III clusters
Verbal ability^#	88.2	7.7	95.7	7.8	0.001	−7.5	0.001	−7.4	0.001	−7.2	0.002
Thinking ability^#	80.5	10.5	97.8	10.3	< 0.0001	−17.3	< 0.0001	−16.7	< 0.0001	− 16.9	< 0.0001
Cognitive efficiency^#	81.1	11.9	94.7	9.9	0.0001	−13.6	< 0.0001	− 13.4	< 0.0001	− 13.3	< 0.0001
Long-term memory^#	66.8	14.3	85.1	12.1	< 0.0001	−18.3	< 0.0001	−17.8	< 0.0001	− 18.3	< 0.0001
Processing speed^#	85.1	14.7	102.0	9.7	< 0.0001	−16.9	< 0.0001	− 16.6	< 0.0001	− 17.2	< 0.0001
Phonemic awareness	88.6	10.8	97.6	8.7	0.002	−8.9	0.002	−8.7	0.002	−8.5	0.004
Working memory^#	84.4	10.7	95.6	11.4	0.0007	− 11.1	0.001	− 11.2	0.001	−11.2	0.001
Cognitive fluency^#	78.3	12.2	91.8	9.9	0.0001	−13.5	< 0.0001	− 13.5	< 0.0001	− 14.8	< 0.0001
Executive processes^#	83.8	13.7	100.8	9.7	< 0.0001	−17.0	< 0.0001	− 17.0	< 0.0001	− 17.1	< 0.0001
BRIEF-Adult
Inhibit	49.3	7.9	47.1	7.0	0.319	2.3	0.319	2.4	0.305	2.0	0.385
Shift	51.8	10.3	48.9	11.9	0.256	2.9	0.391	3.2	0.391	2.9	0.396
Emotional control	51.5	8.6	47.7	10.2	0.067	3.9	0.180	4.0	0.162	3.6	0.225
Self-monitor	49.5	8.6	46.4	9.8	0.212	3.1	0.270	3.2	0.251	3.1	0.291
Initiate	50.5	10.9	49.2	9.4	0.795	1.3	0.677	1.5	0.626	1.5	0.642
Working memory	53.7	11.5	49.4	8.9	0.218	4.3	0.178	4.6	0.112	4.4	0.180
Plan/Organize	50.3	10.9	49.0	13.9	0.587	1.3	0.731	1.7	0.622	1.1	0.772
Task monitor	51.5	11.5	48.7	8.7	0.571	2.8	0.372	3.2	0.240	2.4	0.452
Organization of materials	49.8	8.2	50.3	8.7	0.870	−0.4	0.870	−0.2	0.929	−0.7	0.779
Behavior regulation index	50.8	8.8	47.6	10.5	0.266	3.3	0.266	3.5	0.214	3.3	0.278
Metacognitive index	51.1	10.8	49.2	9.8	0.595	1.9	0.549	2.2	0.441	1.7	0.589
Global executive composite	51.1	10.0	48.3	10.1	0.272	2.8	0.356	3.1	0.264	2.7	0.389

*p-values from the T-test or Wilcoxon rank-sum (Mann-Whitney) test; **Adjusted by age and gender; ***Adjusted by education. LRM Linear Regression Models. ^#Neurocognitive measures are significant under the Bonferroni-Holmes corrections for all the statistical tests simultaneously

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