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Table 1 Patient, polyp and family history characteristics

From: Advanced adenomas may be a red flag for hereditary cancer syndromes

 

N = 42

Mean age at polyp diagnosis, years

44.6 (range 23–57)

Sex, n (%)

 Male

19 (45.2)

 Female

23 (54.8)

Personal History of Synchronous/Metachronous AA

 Yes

5 (11.9)

 No

37 (88.1)

FDR with CRC, n (%)

 Yes

10 (23.8)

 No

32 (76.2)

Colonoscopy Indication

 Symptoms

20 (47.6)

 Screening for FH of CRC

7 (16.7)

 Average Risk Screening

14 (33.3)

 Polyp Surveillance

1 (2.4)

Polyp Size, n (%)

  < 10 mm

2 (4.8)

 10–20 mm

21 (50.0)

 21–30 mm

16 (38.1)

 31–40 mm

2 (4.7)

  > 40 mm

1 (2.4)

Polyp Histology, n (%)

 Tubular adenoma

39 (92.9)

 Tubulovillous adenoma

2 (4.8)

 Villous adenoma

1 (2.4)

Immunohistochemistry Results

 Not performed

29 (69.0)

 Normal

12 (28.6)

 Absence of MLH1/PMS2

1 (2.4)

Meets Amsterdam II Criteria, n (%)

 Yes

3 (7.1)

 No

39 (92.9)

PREMM5 Score, n (%)

  ≥ 5

6 (14.3)

  ≥ 2.5

14 (33.3)

 Unable to calculate*

15 (35.7)

  1. FH Family History, CRC colorectal cancer, FDR First Degree Relative, CRC Colorectal Cancer, PREMM5 Lynch syndrome prediction model
  2. aPREMM5 can only be calculated if there is a personal or family history of cancer. A score of ≥5 meets NCCN criteria for genetic testing. Recent studies have shown increased sensitivity when PREMM5 score is ≥2.5, though this does not meet current NCCN criteria