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Table 1 Patient characteristics in different variants type

From: Biological and clinical impact of central nervous system hemangioblastomas in Chinese patients with von Hippel-Lindau disease: implications for treatment

 

Families

HGB patients(total)

HGB patients (alive)

Male

First operation age in HGB

The average times of operation in HGB

Partial deletion

13

35

33

23

32.8 ± 14.3

1.3 ± 0.8

Large deletion

3

12

10

5

34.8 ± 12.8

1.8 ± 1.4

Frameshift

1

1

1

1

39

1

Missense

15

31

27

20

33 ± 12.3

1.3 ± 0.8

Splicing site mutation

2

6

6

2

40.2 ± 19.1

1.7 ± 1.2

total

34

85

77

43

33.7 ± 13.6

1.4 ± 0.93

P

–

–

–

0.593

0.716

0.628

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287