Preferences for breast cancer prevention among women with a BRCA1 or BRCA2 mutation

Table 1 Respondent Characteristics, N = 598 (unless otherwise noted)

Characteristic	Full Sample (N = 598)
All respondents
Age, mean (SD), years	40.9 (8.2)
Age 40 years or older	335 (56%)
Has children	416 (70%)
Hopes to have children in future (after mutation identified) or undecided^a	268 (45%)
White or Caucasian	558 (93%)
Married/living as married/civil partnership	440 (74%)
Higher education (defined as post-secondary/any college and higher)	401 (67%)
Employed full time	329 (55%)
Country of residence
United States	331 (55%)
United Kingdom	117 (20%)
Australia	119 (20%)
Canada	31 (5%)
Mutation
BRCA1	310 (52%)
BRCA2	273 (46%)
BRCA1 and BRCA2	8 (1%)
Don’t know or not sure	7 (1%)
Mean time since genetic test, years (SD)	4.8 (4.3)
First degree relative with breast cancer	374 (63%)
First degree relative with ovarian cancer	122 (20%)
Risk-reducing treatments
RRBM only	95 (16%)
RRBSO only	112 (19%)
RRBM and RRBSO	198 (33%)
Has taken a prescription medication, such as tamoxifen, raloxifene, or an aromatase inhibitor [anastrazole, exemestane]	33 (6%)
Among women who did not report RRBM surgery
n	305
Very likely or somewhat likely to undergo RRBM in the future^b	193 (63%)
Among women who did not report RRBSO surgery
n	288
Very likely or somewhat likely to undergo RRBSO in the future^c	255 (89%)
All respondents
n^d	587
Assigned to Susan, age 25 years	285 (48%)
Assigned to Susan, age 36 years	302 (51%)

RRBM Risk-reducing bilateral mastectomy, RRBSO Bilateral salpingo oophorectomy, SD Standard deviation
^a Includes women who indicated that they wanted to have children or have more children in the future or were undecided about having children or having more children and women who have children that were born after their BRCA 1 or BRCA2 mutation was identified
^b Based on the question “How likely are you to have a surgery to remove both breasts (risk-reducing bilateral mastectomy) in the future?” with the response choices very likely, somewhat likely, unlikely, very unlikely, don’t know or not sure
^c Based on the question “How likely are you to get your ovaries and fallopian tubes removed in the future?” with the response choices very likely, somewhat likely, unlikely, very unlikely, don’t know or not sure
^dThree respondents did not complete the full survey, thus were not assigned to a Susan age group and did not answer any of the four Susan treatment sequencing questions. An additional four respondents assigned to Susan, age 25 and four respondents assigned to Susan, age 36 also did not answer any of the four Susan treatment sequencing questions presented in the survey. Thus, these 11 respondents are not included in the two Susan group sample totals summarized in Table 1 and were not included in the Susan treatment sequence analysis presented in this article

ISSN: 1897-4287