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Table 1 Clinical History of Patients with a DDR- related Pancreatic Cancer

From: Retrospective review of outcomes in patients with DNA-damage repair related pancreatic cancer

Pt

Sex

Prior cancer

Family historyh

Dx.

age

Clinical stage at dx.

Gene

Variant

Survival (mo.)

Sx.

Chemotherapy

Drug

Duration (mo.)

1

M

–

FDR: Colon (P)

30–35

metastatic

BRCA1

c.34C > T

25.8

No

FOLFIRINOX

5

SDR: Breast (P), Prostate (M), Renal (M)

Erlotinib

1

Gemcitabine, Nab-Paclitaxel

6

2

M

–

FDR: Pancreas (P), Prostate (P), Uterine (M)

55–60

metastatic

BRCA1

c.5080G > T

23.5

Yesa

FOLFIRINOX

3

Gemcitabine, Nab-Paclitaxel

2

Gemcitabine

2

Gemcitabine, Cisplatin

7

3

F

breast

FDR: Breast (M), Colon (P)

40–45

metastatic

ATM

c.2921 + 1G > A

13.7

No

FOLFIRINOX

8

SDR: Colon (P)

4

F

bilateral breast

FDR: Breast (M), Colon (P), Ovarian (M)

50–55

locally advanced

BRCA1

c.2722G > T

111.5

Yes

Gemcitabine

6

FOLFIRINOX

6

SDR: 3 Breast (P)

Gemcitabine, Nab-Paclitaxel

1

Gemcitabine

8

FOLXFOX

6

Irinotecan

3

Nivolumab

13

Nivolumab, Gemcitabine, Carboplatin

1

Nivolumab, Gemcitabine

2

Nivolumab

1

PARPi (Rucaparib)

1

5

F

–

FDR: Pancreas (M), Prostate (P)

60–65

metastatic

ATM

c.7630-2A > C

20.5

No

FOLFIRINOX

14

SDR: Breast (M), 2 Pancreas (M), Prostate (P)

Gemcitabine, Cisplatin

4

6

M

–

FDR: Breast (M), Ovarian (M)

60–65

locally advanced

BRCA2

c.9435_9436del

34.3b

Yesa

FOLFIRINOX

2

SDR: 2 Breast (P)

Gemcitabine, Capecitabine

5

7

M

basal cell carcinoma

SDR: Bladder (M), Breast (P), Colon (P)

70–75

locally advanced

FANCC

c.1642C > T

22.3

No

Gemcitabine, Nab-Paclitaxel

4

FOLFIRINOX

7

8

F

–

FDR: Breast (M), Melanoma (M)

40–45

localized

PALB2

c.487_488delGT

84.4b

Yes

Gemcitabine

5

SDR: Breast (M)

9

F

melanoma, bladder

FDR: Breast (M), Melanoma, 2 Pancreatic, Prostate (P)

80+

localized

ATM

c.6975 + 2 T > C

56.6b

Yes

Gemcitabine

3

10

M

–

FDR: Cholangiocarcinoma

80+

localized

ATM

c.2921 + 1G > A

43.2b

Yes

Gemcitabine

2

SDR: Glioblastoma

11

F

breast

FDR: Breast (M), Prostate (P)

75–80

localized

BRCA2

c.1976_1977insSVA

14.0c

Yes

Gemcitabine

3

SDR: Breast (M), 4 Prostate (M), Prostate (P)

  1. aResectable following chemotherapy. bThese patients have not passed away. cDied due to comorbidities (no recurrence). dFDR: First Degree Relative. eSDR: Second degree relative. f(P): Paternal relative. g(M): Maternal relative. hUnconfirmed cancers/ unconfirmed primaries are not included