Table 4 Association of analyzed SNPs with colon cancer risk
Genotype | Cases, n = 150 (%) | Controls, n = 150 (%) | ORa (95%CI) | p-value |
|---|---|---|---|---|
MMP-1(rs1799750) | ||||
1G/1G | 38 (25.3) | 49 (32.7) | 1 | – |
1G/2G | 75 (50) | 66 (44) | 1.49 (0.87–2.55) | 0.15 |
2G/2G | 37 (24.7) | 35 (23.3) | 1.34 (0.70–2.56) | 0.37 |
MMP-2(rs243865) | ||||
CC | 88 (58.7) | 88 (58.7) | 1 | – |
CT | 53 (35.3) | 54 (36) | 1.01 (0.59–1.67) | 0.99 |
TT | 9 (6) | 8 (5.3) | 1.27 (0.46–3.52) | 0.65 |
MMP-7(rs11568818) | ||||
AA | 52 (34.7) | 53 (35.3) | 1 | – |
AG | 71 (47.3) | 77 (51.3) | 0.96 (0.56–1.65) | 0.90 |
GG | 27 (18) | 20 (13.3) | 1.41 (0.66–2.99) | 0.38 |
MMP-13(rs2252070) | ||||
AA | 79 (52.7) | 70 (46.7) | 1 | – |
AG | 60 (40) | 70 (46.7) | 0.78 (0.50–1.24) | 0.30 |
GG | 11 (7.3) | 10 (6.7) | 0.95 (0.34–2.64) | 0.92 |
MT2A(rs28366003) | ||||
AA | 131 (87.3) | 139 (92.7) | 1 | – |
AG + GGb | 19 (12.7) | 11 (7.3) | 1.76 (0.81–3.83) | 0.15 |