Table 2 Association of analyzed SNPs with breast cancer risk
Genotype | Cases, n = 299 (%) | Controls, n = 299 (%) | ORa (95%CI) | p-value |
|---|---|---|---|---|
MMP-1(rs1799750) | ||||
1G/1G | 80 (26.8) | 80 (26.8) | 1 | – |
1G/2G | 140 (46.8) | 144 (48.2) | 1.01 (0.68–1.46) | 0.99 |
2G/2G | 79 (26.4) | 75 (25.1) | 1.08 (0.70–1.67) | 0.73 |
MMP-2(rs243865) | ||||
CC | 172 (57.5) | 169 (56.5) | 1 | – |
CT | 114 (38.1) | 105 (35.1) | 1.08 (0.77–1.51) | 0.66 |
TT | 13 (4.3) | 25 (8.4) | 0.56 (0.28–1.11) | 0.10 |
MMP-7(rs11568818) | ||||
AA | 106 (35.5) | 93 (31.1) | 1 | – |
AG | 151 (50.5) | 152 (50.8) | 0.87 (0.61–1.24) | 0.44 |
GG | 42 (14) | 54 (18.1) | 0.68 (0.42–1.10) | 0.11 |
MMP-13(rs2252070) | ||||
AA | 142 (47.5) | 146 (48.8) | 1 | – |
AG | 133 (44.5) | 125 (41.8) | 1.12 (0.79–1.59) | 0.53 |
GG | 24 (8) | 28 (9.4) | 0.84 (0.44–1.57) | 0.58 |
MT2A(rs28366003) | ||||
AA | 274 (91.6) | 267 (89.3) | 1 | – |
AG + GGb | 25 (8.4) | 32 (10.7) | 0.73 (0.42–1.27) | 0.27 |