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Table 2 Demographic and Clinical Characteristics in All Patients

From: Adherence to National Comprehensive Cancer Network Guidelines for BRCA testing among high risk breast Cancer patients: a retrospective chart review study

 

Patients

(N = 410)

Demographic characteristics

Sex, n (%)

 Female

390 (95.1)

 Male

20 (4.9)

Age at diagnosis, mean ± SD [median]

52 (12.6) [50.0]

 18–44 years

137 (33.4)

 45–64 years

201 (49.0)

 65+ years

72 (17.6)

Age at diagnosis, categories according to Wood et al.a

  < 40 years

70 (17.1)

 40–49 years

128 (31.2)

 50–59 years

91 (22.2)

 60–69 years

85 (20.7)

  ≥ 70 years

36 (8.8)

Race, n (%)

 White

302 (73.7)

 Black or African American

69 (16.8)

 Asian

27 (6.6)

 Native Hawaiian or Other Pacific Islander

1 (0.2)

 Other

11 (2.7)

Ethnicity, n (%)

 Hispanic/Latino

43 (10.5)

 Non-Hispanic/Latino

354 (86.3)

 Unknown

13 (3.2)

Ashkenazi Jewish ancestry, n (%)

 Yes

78 (19.0)

 No

313 (76.3)

 Unknown

19 (4.6)

Breast cancer pathology

Cancer stage at diagnosis, n (%)

 Stage 0-III (non-metastatic)

286 (69.8)

 Stage IV (metastatic)

124 (30.2)

ER status, n (%)

 Positive

244 (59.5)

 Negative

166 (40.5)

PR status, n (%)

 Positive

206 (50.2)

 Negative

204 (49.8)

HER2 status, n (%)

 Positive

73 (17.8)

 Negative

337 (82.2)

Triple negative, n (%)

126 (30.7)

Nottingham combined histologic grade, n (%)

 GX (undetermined grade)

2 (0.5)

 G1

43 (10.5)

 G2

171 (41.7)

 G3

192 (46.8)

 Unknown

2 (0.5)

Additional primary breast cancer, n (%)

 Yes

27 (6.6)

 No

382 (93.2)

 Unknown

1 (0.2)

Additional clinical information assessed in female patients

(N = 390)

Treated for other cancerb, n (%)

 Yes, Ovarian carcinoma

18 (4.6)

 Yes, Other

10 (2.6)

 No

362 (92.8)

Postmenopausal at diagnosis, n (%)

 Yes

185 (47.4)

 No

201 (51.5)

 Unknown

4 (1.0)

  1. Abbreviations:BRCA Breast Cancer Gene, ER Estrogen Receptor, HER2 Human Epidermal Growth Factor Receptor 2, NCCN National Comprehensive Cancer Network, PR Progesterone Receptor, SD Standard Deviation
  2. aQuality of Cancer Family History and Referral for Genetic Counseling and Testing Among Oncology Practices: A Pilot Test of Quality Measures As Part of the American Society of Clinical Oncology Quality Oncology Practice Initiative. Marie E. Wood, Pamela Kadlubek, Trang H. Pham, Dana S. Wollins, Karen H. Lu, Jeffrey N. Weitzel, Michael N. Neuss, and Kevin S. Hughes. Journal of Clinical Oncology 2014 32:8, 824–829
  3. bPersonal history of cancer in males was not collected, as it was not relevant to determine the risk of BRCA1 and BRCA2 pathogenic variants as per NCCN guidelines