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Table 2 Comparison of PancPRO estimates for the PC screening cohort based on participants’ family history (number of FDR and SDR affected with PC), pathogenic variant status or clinical diagnosis

From: Genetic counselling and personalised risk assessment in the Australian pancreatic cancer screening program

Family History Probability PC susceptibility gene 5-year PC risk Lifetime PC risk n
Mean Lowest Highest Mean Lowest Highest Mean Lowest Highest  
1FDR (overall) 0.431 0.159 0.497 0.014 0.003 0.032 0.109 0.037 0.144 38
1FDR + 1SDRa 0.311 0.159 0.469 0.012 0.02 0.025 0.081 0.05 0.122 8
1FDR + 2SDR 0.463 0.267 0.497 0.011 0.003 0.027 0.119 0.037 0.144 19
1FDR + 3SDR 0.456 0.409 0.482 0.019 0.013 0.032 0.112 0.071 0.128 7
1FDR + 4SDRb 0.473 0.456 0.484 0.024 0.017 0.032 0.108 0.081 0.130 4
2FDR (overall) 0.427 0.047 0.507 0.022 0.009 0.032 0.095 0.027 0.132 30
2FDR 0.409 0.047 0.479 0.023 0.010 0.032 0.088 0.031 0.128 14
2FDR + 1SDR 0.427 0.195 0.483 0.023 0.009 0.032 0.095 0.027 0.125 12
2FDR + 3SDR 0.491 0.477 0.507 0.019 0.010 0.029 0.121 0.104 0.132 4
3FDR (overall) 0.445 0.320 0.501 0.020 0.005 0.032 0.097 0.024 0.142 11
3FDR 0.393 0.320 0.497 0.022 0.013 0.032 0.073 0.024 0.130 5
3FDR + 1SDRb 0.489 0.465 0.501 0.018 0.005 0.032 0.117 0.084 0.142 6
  1. aException made due to early-onset PC +/− personal history of early-onset cancer; b representing one family