Genetic counselling and personalised risk assessment in the Australian pancreatic cancer screening program

Table 2 Comparison of PancPRO estimates for the PC screening cohort based on participants’ family history (number of FDR and SDR affected with PC), pathogenic variant status or clinical diagnosis

Family History	Probability PC susceptibility gene			5-year PC risk			Lifetime PC risk			n
Family History	Mean	Lowest	Highest	Mean	Lowest	Highest	Mean	Lowest	Highest
1FDR (overall)	0.431	0.159	0.497	0.014	0.003	0.032	0.109	0.037	0.144	38
1FDR + 1SDR^a	0.311	0.159	0.469	0.012	0.02	0.025	0.081	0.05	0.122	8
1FDR + 2SDR	0.463	0.267	0.497	0.011	0.003	0.027	0.119	0.037	0.144	19
1FDR + 3SDR	0.456	0.409	0.482	0.019	0.013	0.032	0.112	0.071	0.128	7
1FDR + 4SDR^b	0.473	0.456	0.484	0.024	0.017	0.032	0.108	0.081	0.130	4
2FDR (overall)	0.427	0.047	0.507	0.022	0.009	0.032	0.095	0.027	0.132	30
2FDR	0.409	0.047	0.479	0.023	0.010	0.032	0.088	0.031	0.128	14
2FDR + 1SDR	0.427	0.195	0.483	0.023	0.009	0.032	0.095	0.027	0.125	12
2FDR + 3SDR	0.491	0.477	0.507	0.019	0.010	0.029	0.121	0.104	0.132	4
3FDR (overall)	0.445	0.320	0.501	0.020	0.005	0.032	0.097	0.024	0.142	11
3FDR	0.393	0.320	0.497	0.022	0.013	0.032	0.073	0.024	0.130	5
3FDR + 1SDR^b	0.489	0.465	0.501	0.018	0.005	0.032	0.117	0.084	0.142	6

^aException made due to early-onset PC +/− personal history of early-onset cancer; ^b representing one family

ISSN: 1897-4287