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Table 3 Clinical criteria and frequencies of pathogenic MLH1/MSH2 variants in Pakistani study participants

From: Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients

Clinical diagnostic criteria

N

with pathogenic variants N (%)

without pathogenic variants N (%)

P a

HNPCC

9

5 (55.6)

4 (44.4)

*** < 0.0001b, 0.2047c

suspected-HNPCC

20

5 (25.0)

15 (75.0)

***0.0001 d

non-HNPCC

183

2 (1.1)

181 (98.9)

 

Total cases

212

12 (5.7)

200 (94.3)

 
  1. P values marked in bold are statistically significant
  2. aFisher’s exact test
  3. bHNPCC vs. non-HNPCC
  4. cHNPCC vs. suspected-HNPCC
  5. dsuspected-HNPCC vs. non-HNPCC
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287