Table 1 Clinicopathological characteristics of HNPCC/suspected-HNPCC and non-HNPCC study participants
Characteristics | HNPCC/suspected-HNPCC (n = 27)a | non-HNPCC (n = 183) | P b |
|---|---|---|---|
Age at diagnosis of CRC (yrs) | |||
Mean | 42.7 | 43.1 | 0.951c |
Range | 20–61 | 14–77 | |
< 50 | 21 (77.8) | 115 (62.8) | 0.194 |
> 50 | 6 (22.2) | 68 (37.2) | |
Gender, No (%) | |||
Male | 21 (77.8) | 125 (68.3) | 0.377 |
Female | 6 (22.2) | 58 (31.7) | |
Tumor location, No (%) | |||
Proximal | 14 (58.3) | 24 (13.2) | *** < 0.0001 d |
Distal | 9 (37.5) | 144 (79.6) | |
Colon (not specified) | 1 (4.2) | 13 (7.2) | |
Unknown | 3 | 2 | |
Histologic type, No (%) | |||
Adenocarcinoma | 20 (80.0) | 142 (79.3) | 1.0e |
Mucinous adenocarcinoma | 5 (20.0) | 36 (20.1) | |
Squamous cell carcinoma | 0 | 1 (0.6) | |
Unknown | 2 | 4 | |
Mucinous component, No (%) | |||
Absent | 20 (90.9) | 132 (79.0) | 0.257 |
Present | 2 (9.1) | 35 (21.0) | |
Unknown | 5 | 16 | |
Tumor size (cm), No (%) | |||
< 5 | 11 (45.8) | 50 (70.4) | **0.047 |
> 5 | 13 (54.2) | 21 (29.6) | |
Unknown | 3 | 112 | |
Macroscopic appearance, No (%) | |||
Ulcerative | 5 (50.0) | 17 (34.7) | 0.061f |
Infilterative | 0 | 16 (32.7) | |
Fungating | 0 | 11 (22.4) | |
Infiltrative+ulcerative | 1 (10.0) | 4 (8.2) | |
Fungating+ulcerative | 4 (40.0) | 1 (2.0) | |
Unknown | 17 | 134 | |
Histologic grade, No (%) | |||
Low | 18 (78.3) | 99 (77.3) | 1.0 |
High | 5 (21.7) | 29 (22.7) | |
Unknown | 4 | 55 | |
Lymphovascular invasion, No (%) | |||
Absent | 16 (88.9) | 32 (64.0) | 0.197g |
Present | 2 (11.1) | 14 (28.0) | |
Intermediate | 0 | 4 (8.0) | |
Unknown | 9 | 133 | |
Venous invasion, No (%) | |||
Absent | 8 (100.0) | 31 (79.5) | 0.566g |
Present | 0 | 5 (12.8) | |
Intermediate | 0 | 3 (7.7) | |
Unknown | 19 | 144 | |
Primary tumor, No (%) | |||
pT0-pT2 | 8 (34.8) | 17 (25.0) | 0.421h |
pT3 | 13 (56.5) | 44 (64.7) | |
pT4 | 2 (8.7) | 7 (10.3) | |
Unknown | 4 | 115 | |
Regional lymph nodes, No (%) | |||
pN0 | 11 (47.8) | 33 (50.0) | 1.0i |
pN1 | 7 (30.4) | 15 (22.7) | |
pN2 | 5 (21.7) | 18 (27.3) | |
Unknown | 4 | 117 | |
Ethnicity, No (%) | |||
Punjabi | 10 (37.0) | 72 (39.3) | 0.644j |
Pathan | 11 (40.8) | 62 (33.9) | |
Others | 6 (22.2) | 49 (26.8) | |