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Table 1 Clinicopathological characteristics of HNPCC/suspected-HNPCC and non-HNPCC study participants

From: Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients

Characteristics HNPCC/suspected-HNPCC (n = 27)a non-HNPCC (n = 183) P b
Age at diagnosis of CRC (yrs)
 Mean 42.7 43.1 0.951c
 Range 20–61 14–77  
< 50 21 (77.8) 115 (62.8) 0.194
 > 50 6 (22.2) 68 (37.2)  
Gender, No (%)
 Male 21 (77.8) 125 (68.3) 0.377
 Female 6 (22.2) 58 (31.7)  
Tumor location, No (%)
 Proximal 14 (58.3) 24 (13.2) *** < 0.0001 d
 Distal 9 (37.5) 144 (79.6)  
 Colon (not specified) 1 (4.2) 13 (7.2)  
 Unknown 3 2  
Histologic type, No (%)
 Adenocarcinoma 20 (80.0) 142 (79.3) 1.0e
 Mucinous adenocarcinoma 5 (20.0) 36 (20.1)  
 Squamous cell carcinoma 0 1 (0.6)  
 Unknown 2 4  
Mucinous component, No (%)
 Absent 20 (90.9) 132 (79.0) 0.257
 Present 2 (9.1) 35 (21.0)  
 Unknown 5 16  
Tumor size (cm), No (%)
< 5 11 (45.8) 50 (70.4) **0.047
 > 5 13 (54.2) 21 (29.6)  
 Unknown 3 112  
Macroscopic appearance, No (%)
 Ulcerative 5 (50.0) 17 (34.7) 0.061f
 Infilterative 0 16 (32.7)  
 Fungating 0 11 (22.4)  
 Infiltrative+ulcerative 1 (10.0) 4 (8.2)  
 Fungating+ulcerative 4 (40.0) 1 (2.0)  
 Unknown 17 134  
Histologic grade, No (%)
 Low 18 (78.3) 99 (77.3) 1.0
 High 5 (21.7) 29 (22.7)  
 Unknown 4 55  
Lymphovascular invasion, No (%)
 Absent 16 (88.9) 32 (64.0) 0.197g
 Present 2 (11.1) 14 (28.0)  
 Intermediate 0 4 (8.0)  
 Unknown 9 133  
Venous invasion, No (%)
 Absent 8 (100.0) 31 (79.5) 0.566g
 Present 0 5 (12.8)  
 Intermediate 0 3 (7.7)  
 Unknown 19 144  
Primary tumor, No (%)
 pT0-pT2 8 (34.8) 17 (25.0) 0.421h
 pT3 13 (56.5) 44 (64.7)  
 pT4 2 (8.7) 7 (10.3)  
 Unknown 4 115  
Regional lymph nodes, No (%)
 pN0 11 (47.8) 33 (50.0) 1.0i
 pN1 7 (30.4) 15 (22.7)  
 pN2 5 (21.7) 18 (27.3)  
 Unknown 4 117  
Ethnicity, No (%)
 Punjabi 10 (37.0) 72 (39.3) 0.644j
 Pathan 11 (40.8) 62 (33.9)  
 Others 6 (22.2) 49 (26.8)  
  1. P values marked in bold are statistically significant
  2. CRC Colorectal cancer, pN0 no regional lymph node metastasis, pN1 metastasis in < 3 regional lymph nodes, pN2 metastasis in > 4 regional lymph nodes, pT2, tumor invades through muscularis propria, pT3 tumor invades through muscularis propria into pericolorectal tissues, pT4 tumor directly invades other organs or structures
  3. a One index patient with breast-endometrial cancer and the other with ovarian cancer were not included
  4. b Fisher’s Exact test
  5. c Wilcoxon rank-sum test
  6. d Proximal vs. distal
  7. e Adenocarcinoma vs. mucinous adenocarcinoma
  8. f Ulcerative vs. infiltrative
  9. g Absent vs. present
  10. h pT0-pT2 vs. pT3–4
  11. i pN0 vs. pN1–2
  12. j Punjabi vs. Pathan