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Fig. 1 | Hereditary Cancer in Clinical Practice

Fig. 1

From: Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients

Fig. 1

Pedigrees of HNPCC (a-d and f), suspected-HNPCC (e and g-i) and non-HNPCC (j, k) families with pathogenic/likely pathogenic MLH1 or MSH2 variants. a-k: Include families C203, H707, C202, C162, C92, C143, H1075, C49, C85, C122, and C164, respectively. Circles are females, squares are males, and a diagonal slash indicates a deceased individual. Symbols with filled left upper quadrant: unilateral breast cancer. Symbols with filled right lower quadrant: cancer other than breast, the name of that cancer is mentioned. Identification numbers of individuals are below the symbols. The index patient is indicated by an arrow. A, age; BC, breast cancer; CRC, colorectal cancer; D, death. The numbers following these abbreviations indicate age at enrollment, cancer diagnosis or death. M+, positive for pathogenic/likely pathogenic variant

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