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Fig. 2 | Hereditary Cancer in Clinical Practice

Fig. 2

From: Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study

Fig. 2

Distribution of deleterious germline mutations identified in Pakistani breast/ovarian cancer families across the BRCA1 and BRCA2 genes. Recurrent mutations are marked with (RM). The distribution of breast cancer (BC) and ovarian cancer (OC) in families according to the position of the mutations in BRCA1 (a) and BRCA2 (b) is shown. Regions inferred to be breast cancer cluster regions (BCCRs) and ovarian cancer cluster regions (OCCRs) according to Rebbeck and colleagues [24] are shown at the bottom

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