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Table 1 Associations of ovarian cancer with pathogenic variants in homologous recombination genes among self-reported white women

From: Age-adjusted association of homologous recombination genes with ovarian cancer using clinical exomes as controls

Gene Median Age of PV Carriers (Casesa, Controlsb) Crude Odds Ratio (CI) p-value, Crudec Adjusted Odds Ratio (CI) p-value, Adjustedc Case Carriers, No. (Non-Carriers)d Control Carriers, No. (Non-Carriers) p-value, z-teste
ATM 55.0, 47.0 2.01. (1.15 to 3.64) 0.03 1.72 (0.89 to 3.44) 0.18 35 (4724) 17 (4673) 0.35
BARD1 60.0, 34.5 1.59 (0.31 to 9.56) 0.57 6.30 (0.55 to 74.25) 0.19 3 (4122) 2 (4688) 0.80
BRCA1 53.0, 37.0 38.46 (17.03 to 115.32) 1.03 × 10−47 47.80 (20.76 to 145.03) 1.87 × 10−46 219 (5944) 4 (4686) 0.60
BRCA2 63.0, 40.0 8.19 (5.22 to 13.67) 1.17 × 10−28 5.10 (3.12 to 8.83) 2.89 × 10−12 193 (5969) 18 (4672) 0.14
BRIP1 67.0, 46.0 2.05 (1.11 to 3.94) 0.03 0.87 (0.41 to 1.93) 0.73 30 (4805) 14 (4676) 0.04
CHEK2 52.0, 42.0 1.62 (1.00 to 2.69) 0.07 2.64 (1.48 to 4.79) 2.36 × 10−3 45 (4923) 24 (4287) 0.79
NBN 64.5, 37.0 0.52 (0.15 to 1.54) 0.27 0.45 (0.10 to 1.82) 0.33 4 (4232) 9 (4681) 0.46
PALB2 62.0, 39.0 2.06 (0.90 to 5.19) 0.11 1.78 (0.61 to 5.59) 0.33 16 (5004) 7 (4683) 0.50
RAD51C 61.0, 39.0 15.28 (3.97 to 137.01) 6.29 × 10−06 12.09 (2.78 to 114.43) 7.85 × 10−04 23 (4809) 1 (4689) 0.34
RAD51D 60.0, 32.5 7.99 (2.56 to 39.77) 1.97 × 10−04 8.38 (2.17 to 47.23) 2.51 × 10−03 20 (4809) 2 (4688) 0.44
  1. aAge (in years) at time of ovarian cancer diagnosis
  2. bAge (in years) at time of testing
  3. cCorrected for False Discovery Rate
  4. dAll genes were not tested for every sample
  5. eComparing crude odds ratio to adjusted odds ratio
  6. CI Confidence Interval, No. Number