Table 1 Associations of ovarian cancer with pathogenic variants in homologous recombination genes among self-reported white women
Gene | Median Age of PV Carriers (Casesa, Controlsb) | Crude Odds Ratio (CI) | p-value, Crudec | Adjusted Odds Ratio (CI) | p-value, Adjustedc | Case Carriers, No. (Non-Carriers)d | Control Carriers, No. (Non-Carriers) | p-value, z-teste |
|---|---|---|---|---|---|---|---|---|
ATM | 55.0, 47.0 | 2.01. (1.15 to 3.64) | 0.03 | 1.72 (0.89 to 3.44) | 0.18 | 35 (4724) | 17 (4673) | 0.35 |
BARD1 | 60.0, 34.5 | 1.59 (0.31 to 9.56) | 0.57 | 6.30 (0.55 to 74.25) | 0.19 | 3 (4122) | 2 (4688) | 0.80 |
BRCA1 | 53.0, 37.0 | 38.46 (17.03 to 115.32) | 1.03 × 10−47 | 47.80 (20.76 to 145.03) | 1.87 × 10−46 | 219 (5944) | 4 (4686) | 0.60 |
BRCA2 | 63.0, 40.0 | 8.19 (5.22 to 13.67) | 1.17 × 10−28 | 5.10 (3.12 to 8.83) | 2.89 × 10−12 | 193 (5969) | 18 (4672) | 0.14 |
BRIP1 | 67.0, 46.0 | 2.05 (1.11 to 3.94) | 0.03 | 0.87 (0.41 to 1.93) | 0.73 | 30 (4805) | 14 (4676) | 0.04 |
CHEK2 | 52.0, 42.0 | 1.62 (1.00 to 2.69) | 0.07 | 2.64 (1.48 to 4.79) | 2.36 × 10−3 | 45 (4923) | 24 (4287) | 0.79 |
NBN | 64.5, 37.0 | 0.52 (0.15 to 1.54) | 0.27 | 0.45 (0.10 to 1.82) | 0.33 | 4 (4232) | 9 (4681) | 0.46 |
PALB2 | 62.0, 39.0 | 2.06 (0.90 to 5.19) | 0.11 | 1.78 (0.61 to 5.59) | 0.33 | 16 (5004) | 7 (4683) | 0.50 |
RAD51C | 61.0, 39.0 | 15.28 (3.97 to 137.01) | 6.29 × 10−06 | 12.09 (2.78 to 114.43) | 7.85 × 10−04 | 23 (4809) | 1 (4689) | 0.34 |
RAD51D | 60.0, 32.5 | 7.99 (2.56 to 39.77) | 1.97 × 10−04 | 8.38 (2.17 to 47.23) | 2.51 × 10−03 | 20 (4809) | 2 (4688) | 0.44 |