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Fig. 4 | Hereditary Cancer in Clinical Practice

Fig. 4

From: Endometrioid endometrial cancer “recurring” as high-grade serous adenocarcinoma in the inguinal lymph nodes in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?

Fig. 4

Confirmed Lynch syndrome in the patient. a. Immunohistochemical analysis of mismatch repair (MMR) genes for the primary endometrial cancer (original magnification × 10, bar = 200 μm). (a) negative for MLH1. (b) positive for MSH2. (c) positive for MSH6. (d) weakly positive for PMS2. All antibodies are from DAKO. b. MMR genes for the metastatic serous adenocarcinoma in the inguinal lymph node (original magnification × 10, bar = 200 μm). (a) negative for MLH1. (b) negative for PMS2. c. Germline mutation analysis of MLH1. A germline MLH1 (NM_000249) heterozygote gene mutation (c.2089_2090delCT) was identified in the patient

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287