Table 2 Characteristics of studies included in meta-analysis
Author, Year | Sharif et al., 2007 [9] | Wang et al., 2012 [20] | Madanikia et al., 2012 [18] | Seminog et al. (2015) [21] |
|---|---|---|---|---|
Country | United Kingdom | United States | United States | United Kingdom |
Type of Study | Retrospective population-based cohort | Retrospective cohort | Retrospective cohort | Retrospective population-based case-controlled cohort |
NOS Score | ||||
 Selection | ⋆⋆⋆ | ⋆⋆⋆⋆ | ⋆⋆ | ⋆⋆ |
 Comparability | ⋆⋆ | ⋆ | ⋆⋆ | ⋆⋆ |
 Outcome/Exposure | ⋆⋆⋆ | ⋆⋆ | ⋆⋆ | ⋆⋆ |
Study Period | 1975–2005 | 1990-2009 | 1995–2010 | 1999–2011 |
NF1 Patient Identification | Regional Genetic Service registry | Medical Genetics Clinic database and Henry Ford Hospital electronic medical records | Johns Hopkins Comprehensive Neurofibromatosis Center Registry | England NHS Information Center database and Center for National Statistics |
Breast Cancer Diagnosis | North Western Cancer Registry | Metropolitan Detroit Cancer Surveillance System database | Johns Hopkins medical records and Oncology Clinical Information System | England NHS Information Center database and Center for National Statistics |
Start of Follow-Up | January 1, 1975 or 20th birthday | January 1, 1973 or 20th birthday | 20th birthday | Exposure: 1st hospital record for NF1Control: 1st hospital record of minor medical condition |
End of Follow-up | Date of breast cancer diagnosis, last follow-up, or death | Date of breast cancer diagnosis or death | Date of breast cancer diagnosis or death | First hospital record for breast cancer or death |
No. of Cases/Sample Size | 14/304 | 11/76 | 4 / 126 | 58 / 3672 |
Age (years): Risk Estimates (95% CI) | SIR All ages: 3.5 (1.9–5.9) < 50: 4.9 (2.4–8.8) | SIR All ages: 5.2 (2.4–9.8) ≥ 50: 2.8 (0.6–8.2) < 50: 8.8 (3.2–19.2) 40–49: 4.4 (0.5–16.1) 30–39: 19.5 (5.3–50) | SIR All ages: 1.71 (0.54–4.12) ≥ 50: 0.81 (0.04–4.01) <  50: 2.68 (0.68–7.29) | RR 30–39: 6.5 (2.6–13.5) 40–49: 4.4 (2.5–7.0) 50–59: 2.6 (1.5–4.2) 60–69: 1.9 (1.0–3.3) 70–79: 0.8 (0.2–2.2) |
Adjusted Factors | Age, calendar-period | Age | Age, calendar-period, race, time period of incidence | Age, calendar-period, region of residence, quintile of socioeconomic status |