Table 1 Characteristics of 16 patients who developed cancer after risk-reducing salpingo-oophorectomy
Patient number | BRCA1 mutation type | Cancer diagnosed before prophylactic surgery (yes/no) location | Date of prophylactic surgery (month/year) | Date of cancer diagnosis after prophylactic surgery (month/year) | Cancer diagnosed after prophylactic surgery (location) | Time from risk-reducing surgery to cancer diagnosis (months) |
|---|---|---|---|---|---|---|
1. | c.5266dupC | Yes breast | 02/2008 | 06/2008 | breast - second primary | 4 |
2. | c.5266dupC | Yes breast | 06/2006 | 04/2008 | breast -recurrence | 22 |
3. | c.181T > G | Yes breast | 09/1999 | 11/2004 | peritoneum | 62 |
4. | c.5266dupC | Yes breast | 11/2002 | 05/2004 | breast -recurrence | 18 |
5. | c.181T > G | Yes breast | 02/2001 | 08/2003 | peritoneum | 30 |
6. | c.5266dupC | Yes breast | 01/2002 | 04/2008 | breast -recurrence | 75 |
7. | c.181T > G | no | 08/2003 | 06/2008 | breast - primary | 58 |
8. | c.5266dupC | no | 06/2002 | 10/2006 | breast - primary | 52 |
9. | c.5266dupC | Yes breast | 09/2001 | 01/2002 | breast -recurrence | 4 |
10. | c.5266dupC | no | 11/2001 | 01/2008 | breast - primary | 74 |
11. | c.5266dupC | no | 04/2006 | 03/2008 | breast - primary | 23 |
12. | c.5266dupC | Yes breast | 06/2004 | 06/2006 | breast - second primary | 24 |
13. | c.4035delA | no | 11/2002 | 07/2009 | breast primary | 80 |
14. | c.181T > G | Yes breast | 05/2000 | 09/2012 | breast - second primary | 148 |
15. | c.5266dupC | Yes breast | 07/2002 | 03/2003 | breast -recurrence | 8 |
16. | c.5266dupC | no | 11/2000 | 06/2003 | breast - primary | 31 |