BRCA mutation screening and patterns among high-risk Lebanese subjects

Table 5 Studies examining BRCA1 & 2 mutations in Middle East and North Africa region from 2015 to 2018

Region	Case selection	Gene region covered	Detection method	Reference
MENA	173 breast cancer and ovarian cancer	All	Parallel sequencing Sanger sequencing	[17]
Lebanon	250 females	All	Sequencing MLPA	[2]
Lebanon	45 families	All	Sequencing Sanger validation	[15]
Tunisia	7 families	All	Sequencing	[18]
Tunisia	92 families		Review	[11]
Jordan	100 BC females	All	BRCA sequencing	[10]
Saudi Arabia	818 BC patients	All	Capture or Sanger sequencing	[19]
Morocco	6 families - 15 patients	All	Next generation sequencing	[13]
Morocco	40 patients	All	Sequencing	[12]
Morocco	122 patients	c.1310_1313delAAGA	Sanger sequencing Next generation sequencing	[20]
Palestine	875 patients	BROCA panel	Parallel Sequencing	[14]
Saudi Arabia	310 patients	BRCA1 and BRCA2	Next generation sequencing Sanger sequencing	[9]

ISSN: 1897-4287