The association between non-breast and ovary cancers and BRCA mutation in first- and second-degree relatives of high-risk breast cancer patients: a large-scale study of Koreans

Table 1 Clinical characteristics according to BRCA mutation status (n = 2555)

Characteristics	BRCA (−) (n = 2178)	BRCA (+) (n = 377)	p value
Age [years; median (range)]	39 (19–82)	40 (23–75)	0.996
Risk factors
Family history of breast or ovarian cancer
No	1310 (60.1%)	105 (27.9%)	< 0.001
Yes	868 (39.9%)	272 (72.1%)	< 0.001
Age at diagnosis
> 40	1371 (62.9%)	245 (65.0%)	0.448
≤ 40	807 (37.1%)	132 (35.0%)	0.448
Bilateral breast cancer
No	1978 (90.8%)	328 (87.0%)	0.021
Yes	200 (9.2%)	49 (13.0%)	0.021
Gender
Female	2165 (99.4%)	371 (98.4%)	0.038
Male	13 (0.6%)	6 (1.6%)	0.038
Number of risk factors
Single	2013 (92.4%)	274 (72.7%)	< 0.001
Multiple	165 (7.6%)	103 (27.3%)	< 0.001

The relationships between the distributions of risk factors and BRCA mutation were examined by chi-square test. The t-test was applied for comparing the distribution of age

ISSN: 1897-4287