Table 7 Observed cancer cases for the MSH2 cohort with 100% or 50% probability of MMR mutation (excluding colorectal and endometrial cancer)
From: A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families
Primary site | Observed number | Proportion [%] | LL 95% | UL 95% | Proportion [%] in Sweden 1970 | Proportion [%] in Sweden 2010 | Reference outside CI |
|---|---|---|---|---|---|---|---|
Kidney/urinary tract excl prostate | 47 | 21.56 | 16.06 | 27.06 | 8.93 | 5.87 | above |
Stomach | 30 | 13.76 | 9.17 | 18.35 | 6.44 | 1.41 | above |
Skin excl melanoma | 24 | 11.01 | 6.88 | 15.14 | 1.87 | 4.54 | above |
Ovary and Fallopian tube | 20 | 9.17 | 5.5 | 13.3 | 4.86 | 1.92 | above |
Prostate | 17 | 7.8 | 4.59 | 11.47 | 5.26 | 13.07 | No |
Breast | 15 | 6.88 | 3.67 | 10.55 | 16.64 | 23.03 | below |
Brain and nervous system | 12 | 5.5 | 2.75 | 8.72 | 6.19 | 5.13 | No |
Cervix | 11 | 5.05 | 2.29 | 8.26 | 5.86 | 2.08 | No |
Small bowel | 8 | 3.67 | 1.38 | 6.42 | 0.54 | 0.56 | above |
Blood and lymphatic tissue | 8 | 3.67 | 1.38 | 6.42 | 9.98 | 9.29 | below |
Malignant melanoma | 6 | 2.75 | 0.92 | 5.05 | 4.51 | 9.58 | No |
Pancreas | 4 | 1.83 | 0.46 | 3.67 | 2.81 | 1.63 | No |
Lung and airways | 4 | 1.83 | 0.46 | 3.67 | 7.12 | 5.49 | below |
Liver and biliary system | 3 | 1.38 | 0 | 3.21 | 2.57 | 1.65 | No |
Thyroid | 3 | 1.38 | 0 | 3.21 | 1.63 | 2.02 | No |
Oesophagus | 2 | 0.92 | 0 | 2.29 | 0.76 | 0.62 | No |
Bone and soft tissue | 2 | 0.92 | 0 | 2.29 | 1.59 | 1.07 | No |
Testicle | 1 | 0.46 | 0 | 1.38 | 1.63 | 3.12 | below |
Penis | 1 | 0.46 | 0 | 1.38 | 0.34 | 0.18 | No |
Head and neck | 0 | 0 | 0 | 0 | 3.67 | 2.97 | below |
Female genital organ | 0 | 0 | 0 | 0 | 0.48 | 0.3 | below |
Eye | 0 | 0 | 0 | 0 | 0.46 | 0.34 | below |
Endocrine cancer | 0 | 0 | 0 | 0 | 2.5 | 1.99 | below |
Unspecified location | 0 | 0 | 0 | 0 | 3.34 | 2.13 | below |