CD36 – a plausible modifier of disease phenotype in familial adenomatous polyposis

Table 2 Population I (FAP and AFAP): The table lists combination of genotypes (1 = wildtype genotype, 2 = heterozygote genotype and 3 = variant genotype) and phenotypic FAP group (1 = APC, 2 = APC MCR and 3 = APC AFAP) for each SNP and age where 50% of population I is polyposis free for each genotype. The mutation group/SNP interaction is the p-value from a joint test of the interaction parameters of a Cox model

SNP genotype	Age where 50% of population is polyposis free for each genotype^a									Test equality of survivor functions			Cox model Mutationgroup/SNP interaction
	APC (mutation group 1)			APC MCR (mutation group 2)			APC AFAP (mutation group 3)			p-values			p-values Wald-test
	1	2	3	1	2	3	1	2	3	Log-Rank	Tarone-ware	Wilcoxon
rs1049673	38	37	29	29	25	36	49	46	38	0.0082	0.0062	0.0057	0.3090
rs1761667	39	37	34	36	41	16	58	38	49	0.0010	0.0011	0.0015	0.0663
rs1984112	35	37	39	16	32	42	49	42	51	0.0036	0.0007	0.0001	0.4608

ISSN: 1897-4287