Gene | Syndrome | Associated Cancers/tumours | Estimated lifetime pancreatic cancer risk (to 70–80 years) | Included on the 30 gene panel |
---|---|---|---|---|
STK11 | Peutz Jeghers syndrome | Breast, GI (pancreatic), gynecologic, nasal polyps | 11–32% | Yes |
PRSS1 | Hereditary Pancreatitis | Pancreatic | 20%–40% | No |
CDKN2A/CDK4 | Familial Melanoma (Pancreatic) Syndrome | Melanoma, pancreatic | 17% | Yes |
BRCA1/BRCA2 | Hereditary Breast and Ovarian Cancer syndrome | Breast, ovarian, prostate, male breast, pancreatic | 2%–8% | Yes |
MLH1, MSH2, MSH6, PMS2, EPCAM | Lynch syndrome | Colon, uterine, ovarian, pancreatic | 3%–4% | Yes |
APC | Familial Adenomatous Polyposis | Colon, small intestine, desmoid | Elevated, not defined | Yes |
TP53 | Li Fraumeni syndrome | Breast (young), sarcoma, brain, adrenocortical, leukemia | Elevated, not defined | Yes |
PALB2 | familial pancreatic cancer | Breast, pancreatic | Elevated, not defined | Yes |
ATM | familial pancreatic cancer | Breast, pancreatic | Elevated, not defined | Yes |