Central nervous system gadolinium accumulation in patients undergoing periodical contrast MRI screening for hereditary tumor syndromes

Table 3 Results of correlation and linear regression analysis

Number of MRIs	Regression Coefficient	95% CI	Standardized Regression Coefficient	Significance
VHL
vs. SI Ratio right DN/pons	0.004	0,001–0,008	0.472	0.013
vs. SI Ratio left DN/pons	0.005	0,001–0,008	0.487	0.01
vs. SI Ratio right GP/pons	0.008	0,003–0,013	0.563	0.002
vs. SI Ratio left GP/pons	0.009	0,004–0,013	0.633	<0,001
TSC
vs. SI Ratio right DN/pons	0.002	0,000–0,004	0.402	0.071
vs. SI Ratio left DN/pons	0.002	−0.006	0.368	0.101
vs. SI Ratio right GP/pons	0.003	0,000–0,007	0.385	0.063
vs. SI Ratio left GP/pons	0.004	0,000–0,008	0.447	0.029

In both groups, a linear correlation was seen between the number of Gd enhanced MRIs and increase in SI ratio in the dentate nucleus (DN) and globus pallidus (GP). This effect was only statistically significant in the VHL group
vs. = versus

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