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Table 1 Patient characteristics of VHL and TSC groups

From: Central nervous system gadolinium accumulation in patients undergoing periodical contrast MRI screening for hereditary tumor syndromes

Parameter

VHL group

TSC group

Patients included

28

24

Clinical signs of Gadolinium toxicity

0

0

Radiological signs of Gadolinium accumulation

15

10

Mean age (y)

39 (16 to 63)

27 (4 to 67)

Mean number of MRIs (y)

10 (0 to >20)

16 (2 to >20)

Patient sex

 Men

11

11

 Women

17

13

Kidney disease

 No kidney disease

9

3

 Few bilateral cysts

10

5

 Multiple cysts

2

3

 Renal cell carcinoma

7

1

 Angiomyolipomas

/

12

(Ab)normal kidney function

 Stage 1 (eGFR normal >90 ml/min/1.73m2)

25

20

 Gadolinium accumulation

12/25

13/20

 Stage 2 (eGFR 90–60 ml/min/1.73m2)

3

1

 Gadolinium accumulation

2/3

1/1

 Stage 3 (eGFR 30–59 ml/min/1.73m2)

1

3

 Gadolinium accumulation

1/1

2/3

 Abnormal liver function

0

0

  1. Note: data are number of patients, unless indicated otherwise
  2. All patients with AML also had few or multiple bilateral cysts, except for 1 patient with only AML