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Table 1 List of 27 Genes analyzed by the Inherited Cancer Panel

From: Evaluation of a 27-gene inherited cancer panel across 630 consecutive patients referred for testing in a clinical diagnostic laboratory

Gene Set Gene
BRCA BRCA1 (NM_007294.2), BRCA2 (NM_000059.3)
Lynch Syndrome MLH1 (NM_000249.2), MSH2 (NM_000251.1), MSH6 (NM_000179.2), PMS2 (NM_000535.4), EPCAM (NM_002354.2)a
High Risk for Breast and other Hereditary Cancer Syndromes APC (NM_000038.3), BMPR1A (NM_004329.2), CDH1 (NM_004360.2), CDK4 (NM_000075.2), CDKN2A (NM_000077.3), MUTYH (NM_001128425.1)b, PTEN (NM_000314.4), SMAD4 (NM_005359.3), STK11 (NM_000455.4), TP53 (NM_000546.3)
Moderate to Low Risk Genes ATM (NM_000051.3), BARD1 (NM_000465.2), BRIP1 (NM_032043.1), CHEK2 (NM_007194.3), FAM175A (NM_139076.2), NBN (NM_002485.4), PALB2 (NM_024675.3), PRKAR1A (NM_002734.3), RAD51C (NM_058216.1), RAD51D (NM_002878.2)
  1. aMLPA only
  2. bMUTYH-associated polyposis are caused by biallelic mutations in MUTYH