Table 1 Results of histopathology and targeted molecular profiling of the eleven polyps
Tumour ID | Localization | Size (mm) | Histopathological feature | TruSight® Tumor 15 Sequencing | TruSight® mutant allele frequency (%) | Exome Sequencing | WES mutant allele frequency (%) | Validation by SS |
|---|---|---|---|---|---|---|---|---|
T69 | Caecum | 5 | hyperplastic polyp | KRAS p.G12D | 21 | KRAS p.G12D | 8 | confirmed |
T70 | ascending colon | 7 | hyperplastic polyp | BRAF p.V600E | 26 | BRAF p.V600E | 17 | confirmed |
T71 | ascending colon | 7 | hyperplastic polyp | BRAF p.V600E | 28 | BRAF p.V600E | 12 | confirmed |
T72 | ascending colon | 8 | hyperplastic polyp | BRAF p.V600E | 17 | BRAF p.V600E | 14 | confirmed |
T73 | ascending colon | 6 | hyperplastic polyp | – | – | – | – | – |
T74 | transverse colon | 10 | sessile serrated polyp | BRAF p.V600E | 13 | BRAF p.V600E | 10 | confirmed |
T76 | transverse colon | 11 | sessile serrated polyp | BRAF p.V600E | 21 | BRAF p.V600E | 11 | confirmed |
T77 | descending colon | 8 | hyperplastic polyp | – | – | – | – | – |
T78 | descending colon | 4 | hyperplastic polyp | – | – | – | – | – |
T79 | descending colon | 4 | hyperplastic polyp | – | – | – | – | – |
T80 | descending colon | 13 | hyperplastic polyp | – | – | – | – | – |