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Table 1 National surveillance protocols for colorectal and endometrial cancer

From: Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

Center

Series cencored

Colonoscopy

Gynecological examination

Reference no. and additional details

Interval

From-to

Interval

From-to

Modalities in addition to clinical examination

Finland

2014

3 years

1985–2014

1 year

1995-2014

EB, ultrasound, CA12-5

[3, 4, 8]

Denmark

2014

2 years

1991–2014

2 years

1991-2014

US

[9]

Germany

2014

1 year

1995–2014

1 year

1995-2014

US

[10, 17]

Italy

2013

1-2 years (1 year when age > 40 years; adenoma)

1990–2013

2 years (1 years when age > 35 yrs.)

1990-2013

US, Pap smear

[11]

UK (Manchester)

2014

2 years

1994–2014

1 year

1990-2014

Hysteroscopy, US, CA12-5

[6]

Sweden

2014

2 years

1990–2000

1 year

1992-2014

US, CA 12-5.Some patients: EB

[25, 26]

18 months

2000–2014

Australia

2014

1 year

1990–2014

1 year

1990-2005

US, EB, CA12-5

https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/cp106_0.pdf

https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/cp106_0.pdf

 

2005-2014

Risk reducing surgery only

Spain

2013

1-2 years (1 year when age > 40 years)

1999–2013

1 year

1999-2013

US

Unpublished

The Netherlands

2013

2-3 years

1987–1996

1-2 years

1994-2005

US

[7]

2 years

1997–2013

1-2 years

2005-2013

US, EB

UK (Cardiff)

2013

3 years

1991–1994

1 year

1998-2010

US, CA12-5(3 or 4 monthly)

Unpublished

Colonoscopy 96% compliance with interval.

 

2 years

1994–2013

 

Gyn: only 27% of eligible women had gyn. Cancer screening. Since 2010 not systematic.

UK (Newcastle)

2014

2 years

1995–2014

No fixed

  

Unpublished

Norway

2013

3 years

1989–1996

2 years

1989-2013

US, CA12-5

[5]

2 years (one year when adenoma)

1996–2013

  1. US Transvaginal ultrasound
  2. EB Endometrial biopsy