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Table 3 Other factors associated with bilateral mastectomy during index surgery

From: Preoperative genetic testing impacts surgical decision making in BRCA mutation carriers with breast cancer: a retrospective cohort analysis

 

Unilateral or partial mastectomy

Bilateral mastectomy

p-value

Age

  ≤ 50 (n = 151)

70 (46.4%)

81 (53.6%)

<0.05

  > 50 (n = 69)

43 (62.3%)

26 (37.7%)

<0.05

Race

 Caucasian (n = 189)

98 (51.9%)

91 (48.1%)

NS

 African American (n = 14)

4 (28.6%)

10 (71.4%)

NS

 Other (n = 3)

1 (33.3%)

2 (66.7%)

NS

 Unknown (n = 14)

10 (71.4%)

4 (28.6%)

NS

Laterality

 Unilateral (n = 208)

112 (53.8%)

96 (46.2%)

<0.05

 Bilateral (n = 12)

1 (8.3%)

11 (91.7%)

<0.05

Histology

 DCIS (n = 24)

13 (54.2%)

11 (45.8%)

NS

 IDC (n = 181)

91 (50.3%)

90 (49.7%)

NS

 ILC (n = 13)

9 (69.2%)

4 (30.8%)

NS

 Other (n = 2)

0 (0.0%)

2 (100%)

NS

Grade

 Grade 1 (n = 13)

7 (53.8%)

6 (46.2%)

NS

 Grade 2 (n = 58)

29 (50.0%)

29 (50.0%)

NS

 Grade 3 (n = 140)

71 (50.7%)

69 (49.3%)

NS

 Unknown (n = 9)

6 (66.7%)

3 (33.3%)

NS

Triple negative breast cancer

 Yes (n = 80)

34 (42.5%)

46 (57.5%)

<0.05

 No (n = 92)

43 (46.7%)

49 (53.3%)

NS

 Unknown (n = 48)

36 (75.0%)

12 (25.0%)

<0.05

Overall TNM Stage

 In-situ (n = 24)

13 (54.2%)

11 (45.8%)

NS

 Stage I (n = 79)

50 (63.3%)

29 (36.7%)

<0.05

 Stage II (n = 83)

39 (47.0%)

44 (53.0%)

NS

 Stage III (n = 34)

11 (32.4%)

23 (67.6%)

<0.05

  1. Percentages within parenthesis represent proportions within their respective rows
  2. NS Not significant