Skip to main content

Table 4 Results of the meta-analysis of the association between the ARLTS1 Cys148Arg variant and cancer risk

From: ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis

ARLTS1

CC vs. TT

TC vs. TT

CC + TC vs. TT

CC vs. TC + TT

Cys148Arg

OR (95% CI)

Ph

OR (95% CI)

Ph

OR (95% CI)

Ph

OR (95% CI)

Ph

Total

1.27(1.15,1.41)

0.088

1.10(0.96,1.25)

0.008

1.13(1.02,1.27)

0.039

1.16(1.00,1.35)

0.003

Controls source

 Population

1.38(1.22,1.55)

0.330

1.10(0.95,1.27)

0.033

1.16(1.03,1.30)

0.135

1.26(1.07,1.49)

0.019

 Hospital

1.00(0.81,1.23)

0.476

1.09(0.76,1.57)

0.012

1.06(0.78,1.45)

0.027

0.94(0.79,1.12)

0.739

Study quality

 High

1.35(1.16,1.57)

0.264

1.10(0.94,1.32)

0.005

1.14(1.00,1.31)

0.049

1.14(0.96,1.35)

0.009

 Low & Moderate

1.30(1.07,1.58)

0.023

1.05(0.84,1.31)

0.185

1.12(0.87,1.45)

0.088

1.24(0.86,1.79)

0.037

Type of cancer

 Familial

1.26(1.12,1.43)

0.060

1.11(0.93,1.33)

0.050

1.15(1.02,1.29)

0.065

1.21(0.98,1.49)

0.018

 Sporadic

1.36(1.18,1.55)

0.797

1.08(0.91,1.29)

0.022

1.13(1.02,1.25)

0.203

1.22(1.02,1.46)

0.050

  1. OR odds ratios, 95% CI 95% confidence interval, Ph p-values for heterogeneity in Q-test