Table 2 APC mutation spectrum in Hispanic patients

Cruz-Correa et al. 2013 [43]

Puerto Rico

31

15

c.3183_3187delACAAA

p.Gln1062*

15

c.4612_4613delGA

p.Glu1538Ilefs*5

15

c.3149delC

p.Ala1050Glufs*6

15

c.3927_3931delAAAGA

p.Glu1309Aspfs*4

14

c.1873C > T

p.Gln625*

15

c.4012C > T

p.Gln1338*

Tardin-Torrezan G et al. 2013 [40]

Brazil

23

del 5q21.3-q22.3

8

c.856_859dupCATG

p.Glu287Alafs*2

4

c.447dupC

p.Lys150Glnfs*18

15

c.4097dupC

p.Gln1367Serfs*8

8

c.904C > T

p.Arg302*

15

c.4348C > T

p.Arg1450*

15

c.3880-3881delCA

p.Gln1294Glyfs*6

8

c.847C > T

p.Arg283*

15

c.4099C > T

p.Gln1367*

15

c.3050-3053delATGA

p.Asn1017Metfs*4

15

c.3927-3931delAAAGA

p.Glu1309Aspfs*4

15

c.4393-4394delAG

p.Ser1465Trpfs*3

Zeichner S et al. 2012 [41]

Hispanic

1

15

c.3927_3931delAAAGA

p.Glu1309Aspfs*4

Ricker C et al. 2010 [42]

Mexico, Guatemala, Honduras

9

15

c.3184C > T

p.Gln1062*

15

c.3709delCA (MX)

p.Gln1237Glufs*2

g.89926-?_141606 + ?del (GU)

15

c.3927_3931delAAAGA (MX)

p.Glu1309Aspfs*4

15

c.3803_3815del1 (HO)

p.Pro1268Glufs*16

15

c.3183_3187delACAAA (MX)

p.Gln1062*

InSIGHT [53]

Argentina

15

c.3920 T > A (missense)

p.Ile1307Lys

Portugal

15

c.4687dup

p.Leu1563Profs*4

15

c.5826_5829delCAGA

p.Asp1942Glufs*27

Spain

5

c.637C > T

p.Arg213*

6

c.707delA

p.Gln236Argfs*57

7

c.730_731delAG

p.Arg244Valfs*7

7

c.802G > T

p.Glu268*

8

c.858delT

p.His286Glnfs*7

8

c.904C > T

p.Arg302*

11

c.1412delG

p.Gly471Aspfs*27

13

c.1682dupA

p.Thr562Aspfs*19

13

c.1690C > T

p.Arg564*

14

c.1787C > G

p.Ser596*

14

c.1946_1947insG

p.Asn649Lysfs*2

15A

c.1993_1994delTT

p.Leu665Ilefs*9

15

c.2310delA

p.Glu771Lysfs*6

15B

c.2413C > T

p.Arg805*

15C

c.2496delC

p.Ser833Alafs*9

15D

c.2838_2839delAT

p.Cys947Phefs*15

15D

c.2977A > T

p.Lys993*

15D

c.2980_2990del11

p.Phe994Trpfs*10

15E

c.3224dupA

p.Tyr1075*

15E

c.3251_3252dupAT

p.Lys1085Ilefs*42

15G

c.3921_3924delAAAA

p.Ile1307Metfs*13

15G

c.3927_3931delAAAGA

p.Glu1309Aspfs*4

15

c.4260_4261delCA

p.Ser1421*