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Fig. 1 | Hereditary Cancer in Clinical Practice

Fig. 1

From: A novel deleterious c.2656G>T MSH2 germline mutation in a Pakistani family with a phenotypic overlap of hereditary breast and ovarian cancer and Lynch syndrome

Fig. 1

Pedigree and MSH2 c.2656 G > T (p.Glu886*) carriers of the Pakistani cancer family 326. Circles are females, squares are males, and a diagonal slash indicates a deceased individual. Symbols with filled left upper quadrant: unilateral breast cancer. Symbols with filled upper half: bilateral breast cancer. Symbols with filled left lower quadrant: ovarian cancer. Symbols with filled right lower quadrant: cancer other than breast/ovarian cancer, the name of which is mentioned. Identification numbers of individuals are shown below the symbols. The index patient is indicated by an arrow. ALL, acute lymphoid leukemia; BC, breast cancer; OC, ovarian cancer. The numbers following these abbreviations indicate age at cancer diagnosis. M+, mutation positive. [M+], obligatory mutation carrier. M-, mutation negative

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287