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Fig. 3 | Hereditary Cancer in Clinical Practice

Fig. 3

From: Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer

Fig. 3

Characterization of aberrant splicing fragment. a 8 % polyacrilamide gel electrophoresis of MSH2 cDNA RT-PCR analysis of fragment in a normal control (1) and in the index case (2). SM size marker XIV Roche. The arrow indicates the abnormal band lower than the wild type band (1172 bp) of about 1000 bp. b MSH2 cDNA sequence analysis of abnormal band showing the skipping of exon 11. The arrow indicates the frameshift (between 11 and 12 exons) due to contamination with wild type allele

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287