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Table 2 Clinical features from the intake versus most recent pedigrees in families with BRCAwt and in families with BRCAm

From: Assessing biases of information contained in pedigrees for the classification of BRCA-genetic variants: a study arising from the ENIGMA analytical working group

BRCA genotype families BRCA wild type (n = 118) BRCA pathogenic variant (mutation) (n = 64)
  Intake pedigree Recent pedigree   Intake pedigree Recent pedigree  
  Mean ± SD Mean ± SD p Mean ± SD Mean ± SD p
BRCAPRO score totala 0.281 ± 0.239 0.290 ± 0.242 0.339 0.442 ± 0.306 0.505 ± 0.327 0.006
BRCAPRO 1 scorea 0.160 ± 0.159 0.168 ± 0.170 0.263 0.295 ± 0.227 0.341 ± 0.256 0.005
BRCAPRO 2 scorea 0.121 ± 0.119 0.121 ± 0.117 0.907 0.147 ± 0.175 0.162 ± 0.184 0.151
No. of patients with: Meanc Meanc   Meanc Meanc  
BCb 2.31 2.31 0.746 2.34 2.36 0.636
OCb 0.28 0.32 0.153 0.31 0.33 0.165
BC and OCb 0.06 0.06   0.09 0.16 0.007
Bilateral BCb 0.42 0.43 0.415 0.42 0.47 0.169
BC in menb 0.04 0.04   0.06 0.08 0.161
  1. aPaired t-test. bPoisson log-linear regression model. cStandard errors are in log scale, not shown