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Table 1 Clinical features of families with breast and/or ovarian cancer: wild type (wt) vs. pathogenic variant (mutation; BRCAm)

From: Assessing biases of information contained in pedigrees for the classification of BRCA-genetic variants: a study arising from the ENIGMA analytical working group

  BRCA wt BRCAm  
N = 118 N = 64
  Mean ± SD Mean ± SD P
Proband data    
 BRCAPRO score totala    
 Intake pedigree 0.281 ± 0.239 0.442 ± 0.306 <0.001
 Recent pedigree 0.290 ± 0.242 0.505 ± 0.327 <0.001
 Age of onset of first cancera (in years) 46.27 ± 11.695 43.84 ± 11.776 0.197
  Percentage Percentage  
 Sex (female)b 96.6 100 0.299
 BCb 81.4 81.3 1.000
 OCb 6.8 7.8 0.772
 BC and OCb 3.4 6.2 0.455
 Healthyb 8.5 4.7 0.548
Family datac Meane Meane  
 No. of patients in each pedigree with    
 BCd 2.31 2.34 0.883
 OCd 0.28 0.31 0.730
 BC and OCd 0.06 0.09 0.392
 Bilateral BCd 0.42 0.42 0.985
 BC in mend 0.04 0.06 0.551
  1. aUnivariate Gaussian linear regression model (t-test). bTwo-by-two table (Fisher’s exact test). cBased on intake pedigree. dPoisson log-linear regression model. eStandard errors are in log scale, not shown