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Table 2 Tumour and age characteristics in intensively screened and unscreened women

From: Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer specific and all cause mortality

    MRI/mammography Mammography No screening Total p value
In situ (n = 33, 79.1 %)   Ductal 10 (100) 9 (100) 14 (100) 33 (100) 1.0
  Lobular 0 (0) 0 (0) 0 (0) 0 (0)  
Invasive breast cancer (n = 328, 90.9 %) Type (n = 328) Ductal 24 (96.0) 41 (95.3) 244 (93.8) 309 (94.2)  
  Lobular 1 (4.0) 1 (2.3) 16 (6.2) 18 (5.5)  
  Mixed 0 (0) 1 (2.3) 0 (0) 1 (0.3)  
Age groups (n = 328) <50 years 17 (68.0) 23 (53.5) 168 (64.6) 208 (63.4) 0.330
  > = 50 Years 8 (32.0) 20 (46.5) 92 (35.4) 120 (36.6)  
Nodes (n = 148) 0 18 (78.3) 23 (60.5) 34 (39.1) 75 (50.7)  
  1 2 (8.7) 8 (21.1) 17 (19.5) 27 (18.2)  
  2–3 1 (4.3) 6 (15.8) 17 (19.5) 24 (16.2)  
  4–5 0 (0) 1 (2.6) 9 (10.3) 10 (6.8)  
  6+ 2 (8.7) 0 (0.0) 10 (11.5) 12 (8.1)  
  Missing 2 5 173 180  
Nodes (n = 148) Negative 18 (78.3) 23 (60.5) 34 (39.1) 75 (50.7) 0.001
  Positive 5 (21.7) 15 (39.5) 53 (60.9) 73 (49.3)  
ER-status (n = 211) Negative 3 (18.8) 11 (27.5) 34 (21.9) 48 (22.7) 0.698
  Positive 13 (81.3) 29 (72.5) 121 (78.1) 163 (77.3)  
  Missing 9 3 105 117  
Grade (n = 237) 1 1 (4.3) 4 (10.3) 6 (3.4) 11 (4.6)  
  2 11 (47.8) 15 (38.5) 63 (36.0) 89 (37.6)  
  3 11 (47.8) 20 (51.3) 106 (60.6) 137 (57.8)  
  Missing 2 4 86 91  
Grade (n = 237) 1/2 12 (52.2) 19 (48.7) 69 (39.4) 100 (42.2) 0.338
  3 11 (47.8) 20 (51.3) 106 (60.6) 137 (57.8)  
Censored (n = 328) Alive 25 (100) 38 (88.4) 222 (85.4) 285 (86.9) 0.112
  Dead 0 (0.0) 5 (11.6) 38 (14.6) 43 (13.1)  
Size (n = 186) <10 9 (42.9) 10 (26.3) 9 (7.1) 28 (15.1)  
  10 – 19.9 8 (38.1) 17 (44.7) 55 (43.3) 80 (43.0)  
  20 – 29.9 3 (14.3) 9 (23.7) 36 (28.3) 48 (25.8)  
  30 – 39.9 0 (0.0) 1 (2.6) 12 (9.4) 13 (7.0)  
  40 – 49.9 0 (0.0) 1 (2.6) 7 (5.5) 8 (4.3)  
  > = 50 1 (4.8) 0 (0.0) 8 (6.3) 9 (4.8)  
   Missing 4 5 133 142  
  Size (n = 186) <20 17 (81.0) 27 (71.1) 64 (50.4) 108 (58.1) 0.006
   > = 20 4 (19.0) 11 (28.9) 63 (49.6) 78 (41.9)