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Table 3 Clinical and pathological ovarian cancer characteristics determined by the BRCA1 gene status

From: Clinical features and outcomes of germline mutation BRCA1-linked versus sporadic ovarian cancer patients

Status BRCA1

Wild type (n = 108)

Germline mutation (n = 17)

Statistics

p value

Median (range) age at diagnosis in years

56 (28–85)

47 (39–70)

−2.859a

0.004

Performance status WHO:

 ▪ 0

15

4

  

 ▪ Other

93

13

0.44b

0.51

FIGO stage:

 ▪ Early (I, II)

22

3

  

 ▪ Advanced (III,IV)

86

14

0.07b

0.95

Chemotherapy regimen:

 ▪ With paclitaxel

97

16

  

 ▪ Without paclitaxel

11

1

0.01b

0.91

Chemotherapy regimen:

 ▪ With cisplatin

47

8

  

 ▪ With carboplatin

61

9

0.1c

0.75

Type of histology:

 ▪ Serous

57

11

  

 ▪ Other

51

6

0.84c

0.36

Grading:

 ▪ 1 and 2

38

7

  

 ▪ 3 and unspecified

70

10

0.23c

0.63

Primary surgery:

 ▪ Optimal (<1 cm)

68

9

  

 ▪ Suboptimal (>1 cm)

40

8

0.62c

0.43

  1. aMann–Whitney U test
  2. bYates-corrected Chi-square test
  3. cChi-square test