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Table 3 Correlation between the genotype frequencies of the polymorphisms and the hormone receptors (overall)

From: Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes

  Estrogen Progesterone Her-2
Polymorphisms Negative Positive Negative Positive Negative Positive Inconclusive
rs3803662 - TT N (%) 13 (16.5) 20 (18.0) 16 (18.0) 17 (16.5) 23 (16.9) 7 (14.9) 3 (100.0)
rs3803662 - TC N (%) 33 (41.8) 56 (50.5) 51 (41.8) 38 (42,7) 66 (48.5) 21 (44.7) 0 (0.0)
rs3803662 – CC N (%) 33 (41.8) 35 (31.5) 46 (37.7) 35 (39.3) 47 (34.6) 19 (40.4) 0 (0.0)
Total 79 (100.0) 111 (100.0) 122 (100.0) 89 (100.0) 136 (100.0) 47 (100.0) 3 (100.0)
P value a 0.257 0.504 0.469
rs2981582 – TT N (%) 15 (219.2) 31 (27.2) 16 (18.0) 30 (28.6) 33 (23.9) 21 (25.5) 1 (33.4)
rs2981582 – TC 38 (48.7) 60 (52.6) 47 (52.8) 52 (49.5) 65 (47.1) 28 (59.6) 2 (66.6)
N (%)        
rs2981582 – CC 25 (32.1) 23 (20.2) 26 (29.2) 23 (21.9) 40 (29.0) 7 (14.9) 0 (0.0)
N (%)        
Total 78 (100.0) 114 (100.0) 89 (100.0) 105 (100.0) 138 (100.0) 47 (100.0) 3 (100.0)
P value a 0.054 0.076 0.120
rs13281615 - AA N (%) 20 (25.3) 30 (26.3) 26 (28.9) 25 (23.8) 32 (23.2) 14 (29.2) 2 (66.6)
rs13281615 - AG N (%) 35 (44.3) 56 (49.1) 40 (44.4) 51 (48.6) 68 (49.3) 20 (41.7) 1 (33.4)
rs13281615 - GG N (%) 24 (30.4) 28 (24.6) 24 (26.7) 29 (27.6) 38 (27.5) 14 (29.2) 0 (0.0)
Total 79 (100.0) 114 (100.0) 90 (100.0) 105 (100.0) 138 (100.0) 48 (100.0) 3 (100.0)
P valuea 0.523 0.566 0.291
rs889312 - CC N (%) 12 (15.2) 15 (13.2) 10 (11,1) 17 (16.2) 21 (15.2) 5 (10.4) 0 (0.0)
rs889312 - CA N (%) 35 (44.3) 54 (47.4) 45 (50.0) 45 (42.9) 61 (44.2) 25 (52.1) 1 (33.3)
rs889312 - AA N (%) 32 (40.5) 45 (39.5) 35 (38.9) 43 (41.0) 56 (40.6) 18 (37.5) 2 (66.7)
Total 79 (100.0) 114 (100.0) 90 (100.0) 105 (100.0) 138 (100.0) 48 (100.0) 3 (100.0)
P value a 0.921 0.760 0.554
rs3817198 - TT N (%) 42 (53.8) 51 (44.7) 49 (55.1) 45 (42,9) 68 (49.3) 21 (44.7) 0 (0.0)
rs3817198 - TC N (%) 31 (39,7) 54 (47.4) 34 (38.2) 52 (49,5) 59 (42.8) 23 (48.9) 3 (100)
rs3817198 - CC N (%) 5 (6.4) 9 (7.9) 6 (6.7) 8 (7.6) 11 (8.0) 3 (6.4) 0 (0.0)
Total 78 (100.0) 114 (100.0) 89 (100.0) 105 (100.0) 138 (100.0) 47 (100.0) 3 (100.0)
P value a 0.248 0.145 0.449
  1. Values in bold indicate statistical significance (p < 0.05)
  2. aChi-square