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Table 2 Correlations between the genotype frequencies of the polymorphisms and the family history of cancer (overall)

From: Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes

 

Number of cancer cases

Presence of bilateral breast cancer

Presence of ovarian cancer

Number of generations with cancer

Number of breast cancer cases

Polymorphism

≤3

>3

Yes

No

Yes

No

1

2

3

4

≤3

>3

rs3803662 – TT

13

21

4

30

4

30

8

17

8

1

25

9

N (%)

(20.0)

(15.3)

(20.0)

(16.5)

(14.3)

(17.2)

(22.2)

(17.9)

(12.5)

(16.7)

(17.6)

(15.3)

rs3803662 - TC

25

73

9

89

15

83

15

44

35

4

63

34

N (%)

(38.5)

(53.3)

(45.0)

(48.9)

(53.6)

(47.7)

(41.7)

(46.3)

(54.7)

(66.7)

(44.4)

(57.6)

rs3803662 - CC

27

43

7

63

9

61

13

34

21

1

54

16

N (%)

(41.5)

(31.4)

(35.0)

(34.6)

(32.1)

(35.1)

(36.1)

(35.8)

(32.8)

(16.7)

(38.0)

(27.1)

Total N (%)

65 (100.0)

137 (100.0)

20 (100.0)

182 (100)

28 (100)

245 (100.0)

36 (100)

95 (100)

64 (100)

6 (100)

142 (100)

59 (100)

P value a

(p = 0.602)

(p = 0.849)

(p = 0.998)

(p = 0.890)

(p = 0.429)

rs2981582 - TT

17

32

4

45

2

47

6

28

12

3

33

15

N (%)

(25.8)

(23.2)

(20.0)

(24.5)

(7.5)

(26.6)

(10.7)

(29,5)

(18,2)

(50,0)

(23,1)

(25,0)

rs2981582 - TC

28

76

13

91

18

86

16

44

42

1

70

34

N (%)

(42.4)

(55.1)

(65.0)

(49.5)

(66.6)

(48.6)

(44.4)

(46.3)

(63.6)

(16.7)

(59.0)

(56.7)

rs2981582 - CC

21

30

3

48

7

44

14

23

12

2

40

11

N (%)

(31.8)

(21.7)

(15.0)

(26.1)

(25.9)

(24.9)

(38.9)

(24,2)

(18.2)

(33.3)

(28.0)

(18.3)

Total N (%)

120

156

20

184

27

177

36

95

66

6

143

60

 

(100.0)

(100)

(100.0)

(100)

(100)

(100.0)

(100)

(100)

(100)

(100)

(100)

(100)

P value a

(p = 0.475)

(p = 0.688)

(p = 0.163)

(p = 0.172)

(p = 0.283)

rs13281615 - AA

21

31

3

49

11

41

14

22

16

0

37

15

N (%)

(31.8)

(22.3)

(15.0)

(26.5)

(39.3)

(23.2)

(38.9)

(23.2)

(23.9)

(0.0)

(25.7)

(25.0)

rs13281615 - AG

37

61

5

93

12

86

16

51

27

3

70

27

N (%)

(56.1)

(43.9)

(25.0)

(50.3)

(42.8)

(48.6)

(44.4)

(53.7)

(40.3)

(50.0)

(48.6)

(45.0)

rs13281615 -GG

8

47

12

43

5

50

6

22

24

3

37

18

N (%)

(12.1)

(33.8)

(60.0)

(23.2)

(17.9)

(28.2)

(16.7)

(23,2)

(35.8)

(50.0)

(25.7)

(30.0)

Total N (%)

66

139

20

185

28

177

36

95

67

6

144

60

 

(100)

(100)

(100.0)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

P value a

0.004

0.005

0.072

0.007

0.654

N (%)

(16.7)

(11.5)

(25.0)

(11.9)

(7.1)

(14.1)

(11.1)

(14.7)

(13.4)

(0.0)

(14.6)

(10.0)

rs889312 - CA

28

68

12

84

12

84

18

36

36

5

66

30

N (%)

(42.4)

(48.9)

(60.0)

(45.4)

(42.9)

(47.5)

(50.0)

(37.9)

(53.7)

(83.3)

(45.8)

(50.0)

rs889312 - AA

27

55

3

79

14

68

14

45

22

1

57

24

N (%)

(40.9)

(39.6)

(15.0)

(42.7)

(50.0)

(38.4)

(38.9)

(47.4)

(32.8)

(16.7)

(39.6)

(40.0)

Total N (%)

66 (100)

139

20

185

28

177

36

95

67

6

144

60

  

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

P value a

0.707

0.011

0.179

0.373

0.632

rs3817198 - TT

31

67

6

92

18

80

21

41

33

2

70

28

N (%)

(47.0)

(48.6)

(30.0)

(50.0)

(66.7)

(45.2)

(58.3)

(43.2)

(50.0)

(33.3)

(49.0)

(46.7)

rs3817198 - TC

25

64

10

79

6

83

13

48

24

4

61

28

N (%)

(37.9)

(46.4)

(50.0)

(42.9)

(22.2)

(46.9)

(36.1)

(50.5)

(36.4)

(66.7)

(42.7)

(46.7)

rs3817198 - CC

10

7

4

13

3

14

2

6

9

0

12

4

N (%)

(15.2)

(5.1)

(20.0)

(7.1)

(11.1)

(7.9)

(5.6)

(6.3)

(13.6)

(0.0)

(8.4)

(6.6)

Total N (%)

66

138

20

184

27

177

36

95

66

6

143

60

 

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

(100)

P value a

0.223

0.029

0.166

0.275

0.954

  1. Values in bold indicate statistical significance (p < 0.05)
  2. aChi-square
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287