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Table 1 Frequency of polymorphisms rs3803662 (TNRC9), rs2981582 (FGFR2), rs13281615, rs889312 (MAP3K1) and rs3817198 (LSP1) per group

From: Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes

Variable Group 1 Group 2 Group 3 P valuea
N (%) N (%) N (%)
rs3803662 (TNRC9)     0.027
 TT 5 (9.8) 12 (22.6) 17 (17.3)
 CT 27 (52.9) 24 (45.3) 47 (48.0)
 CC 19 (37.3) 17 (32.1) 34 (34.7)
rs2981582 (FGFR2)     0.031
 TT 14 (27.5) 9 (16.7) 26 (26.3)
 CT 22 (43.1) 33 (61.1) 49 (49.5)
 CC 15 (29.4) 12 (22.2) 24 (24.2)
rs13281615 (8q24)     0.029
 AA 14 (27.5) 11 (20.4) 27 (27.0)
 AG 24 (47.1) 26 (48.1) 48 (48.0)
 GG 13 (25.5) 17 (31.5) 25 (25.0)
rs889312 (MAP3K1)     0.029
 CC 8 (15.7) 8 (14.8) 11 (11.0)
 CA 21 (41.2) 20 (37.0) 55 (55.0)
 AA 22 (43.1) 26 (48.1) 34 (34.0)
rs3817198 (LSP1)     0.023
 TT 26 (51.0) 28 (51.9) 44 (44.4)
 TC 22 (43.1) 24 (44.4) 43 (43.4)
 CC 3 (5.9) 2 (3.7) 12 (12.1)
  1. Group 1: women with germline mutations in the BRCA1/BRCA2 genes; Group 2: women with VUS in the BRCA1/BRCA2 genes; Group 3: women WT for the BRCA1/BRCA2 genes; Group 4: control, sporadic group
  2. Values in bold indicate statistical significance (p < 0.05)
  3. aChi-square