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Table 1 Population, microscopic and clinical characteristics of BRCA1-OC patients

From: Prognostic factors in Polish patients with BRCA1-dependent ovarian cancer

  No. of patients Percent
Population, microscopic and clinical characteristics 66 100
Age
 - ≤ 50 years 34 51.5
 - > 50 years 32 48.5
Menopause
 - yes 28 42.4
 - no 38 57.6
No. of births
 - 0 10 15.2
 - 1 27 40.9
 - ≥2 29 43.9
Family history
 - 1st degree relatives with ovarian cancer 8 12.1
 - 1st degree relatives with breast cancer 17 25.8
Coexisting breast cancer
 - yes 9 13.6
Type of BRCA1 gene mutation
 -C61G 31 47
 - 5382insC 21 31.8
 - 4153delAG 6 9.1
 - 189delAG 4 6.1
 - 3819del5 2 3
 - IVS20 + 60ins12 1 1.5
 - 4158A > G 1 1.5
Grading of the tumor
 - G1 2 2.7
 - G2 18 27.3
 - G3 46 70
Histological type
 - serous 27 40.9
 - endometrial 23 34.9
 - undifferentiated 8 12.1
 - mucous 4 6.1
 - clear cell 2 3
 - mezonefroid 2 3
Staging FIGO (2009)
 - I 4 6.1
 - II 11 16.7
 - III 50 75.7
 - IV 1 1.5
Cytoreduction
 - primary 44 66.7
 - interval 22 33.3
The overall extent of cytoreduction
 - optimal 34 51.5
 - suboptimal 32 48.5
The average concentration of CA125 at the beginning of treatment 1113 U/ml  
The average concentration of CA125 at the end of treatment 71 U/ml