Table 3 The occurrence of the c.470 T > CCHEK2gene variant in Polish differentiated thyroid carcinoma (DTC) patients and controls
Group size | Genotypes | p-value | OR (95%CI) | Allele number | p-value | OR (95%CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TT | TC | CC | Allele positivity (TT vs TC+CC) | Total | T | C | Allele frequency | |||||
DTC patients: | All | 602 | 551 (91,53%) | 48 (7,97%) | 3 (0,5%) | 0.009 | 1.73 (1.14-2.65) | 1204 | 1150 (95,51%) | 54 (4,49%) | 0.004 | 1.81 (1.20-2.72) |
By cancer type: | PTC | 535 (88,87%) | 491 (91,78%) | 41 (7,66%) | 3 (0,56%) | 0.019 | 1.68 (1.08-2.60) | 1070 | 1023 (95,61%) | 47 (4,39%) | 0.008 | 1.77 (1.15-2.70) |
FTC | 67 (11,13%) | 60 (89,55%) | 7 (10,45%) | n.o. | 0.062 | 2.19 (0.94-5.08) | 134 | 127 (94,78%) | 7 (5,22%) | 0.096 | 2.12 (0.93-4.82) | |
By gender: | DTC females | 527 (87,54%) | 479 (90,89%) | 45 (8,54%) | 3 (0,57%) | 0.017 | 1.72 (1.08-2.74) | 1082 | 1031 (95,29%) | 51 (4,71%) | 0.001 | 1.80 (1.14-2.82) |
DTC males | 75 (12,46%) | 72 (96%) | 3 (4%) | n.o. | 0.963 | 0.97 (0.26-3.57) | 156 | 153 (98,08%) | 3 (1,92%) | 1.009 | 0.97 (0.27-3.52) | |
Controls | All | 829 | 787 (94,93%) | 42 (5,07%) | n.o. | - | - | 1658 | 1616 (97,47%) | 42 (2,53%) | - | - |
By gender: | Females | 562 (67,8%) | 531 (94,48%) | 31 (5,52%) | n.o. | - | - | 1124 | 1093 (97,24%) | 31 (2,76%) | - | - |
Males | 267 (32,2%) | 256 (95,88%) | 11 (4,12%) | n.o. | - | - | 534 | 523 (97,94%) | 11 (2,06%) | - | - | |