Table 1 Clinical and pathological characteristics ofBRCA1mutation carriers (n = 18) and non-carriers (n = 32)
Characteristics | BRCA1mutation carriers, n (%) | BRCA1mutation non-carriers, n (%) | P-value |
|---|---|---|---|
Age at diagnosis, years | |||
Median | 46 | 55 | 0.0648 |
Range | 27-72 | 28-78 | |
T stage | |||
T1 | 7 (38.89) | 6 (18.75) | 0.1797 |
T2 | 7 (38.89) | 15 (46.88) | 0.7676 |
T3 | 1 (5.56) | 9 (28.13) | 0.0731 |
T4 | 3 (16.67) | 2 (6.25) | 0.3363 |
Nodal status | |||
N0 | 12 (66.67) | 19 (59.38) | 0.7637 |
N1 | 0 (0.00) | 4 (12.50) | 0.2828 |
N2 | 5 (27.28) | 6 (18.75) | 0.4944 |
N3 | 1 (5.56) | 3 (9.38) | 0.9999 |
Metastasis | |||
M0 | 17 (94.44) | 31 (96.88) | 0.9999 |
M1 | 1 (5.56) | 1 (3.13) | 0.9999 |
Stage | |||
I | 7 (38.89) | 5 (15.63) | 0.0889 |
II | 5 (27.78) | 14 (43.75) | 0.3659 |
III | 5 (27.78) | 12 (37.50) | 0.5482 |
IV | 1 (5.56) | 1 (3.13) | 0.9999 |
Histology | |||
Ductal carcinoma | 14 (77.78) | 28 (87.50) | 0.3984 |
Tubular carcinoma | 0 (0.00) | 1 (3.13) | 0.9999 |
Medullary carcinoma | 3 (16.67) | 0 (0.00) | 0.0442 |
Papillary carcinoma | 1 (5.56) | 2 (6.25) | 0.9999 |
No data | 0 (0.00) | 1 (3.13) | |
Tumor grade | |||
Moderately differentiated | 3 (16.67) | 1 (3.13) | 0.1142 |
Poorly differentiated | 12 (66.67) | 27 (84.38) | 0.1142 |
No data | 3 (16.67) | 4 (12.50) | |
Ki-67 | 73 | 70 | 0.6494 |