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Table 3 Characteristics of 13RET-mutation carriers

From: Molecular diagnosis and comprehensive treatment of multiple endocrine neoplasia type 2 in Southeastern Chinese

Patient/Gender

RETmutation

Age

Pre-Ct (ng/L)

CEA (ng/ml)

Tumor size* (cm): L/R

Operative procedure

Histology

pTNM

LNM

Post-Ct (ng/L)

Interval time (years)

F3-III8/F

C634Y

41

1744.0

57.9

1.4/3.2

Reject operation

-

-

-

-

18

F3-III9/F

C634Y

37

206.0

12.2

1.0/0.7

Reject operation

-

-

-

-

18

F3-IV1/M

C634Y

22

11.8

1.8

-/0.3

Reject operation

-

-

-

-

18

F3-IV4/F

C634Y

9

9.8

0.7

0.3/0.2

Reject operation

-

-

-

-

18

F4-III2/F

C634Y

18

118.0

6.8

1.0/1.0

TT + B-VI

MTC

T1N0M0

0/5

<2.0

17

F5-III4/F

C634R

19

24.3

2.9

0.3/0.2

TT

MTC

T1N0M0

NO

<2.0

17

F6-III2/M

C634R

21

20.9

2.7

0.5/0.7

TT + B-VI

MTC

T1N0M0

0/3

<2.0

26

F6-III4/M

C634R

21

1769.0

119.6

1.1/1.0

TT + B-VI + R-LND

MTC

T1N1bM0

20/59

975.0

23

F6-III5/F

C634R

19

71.4

3.3

0.5/1.0

TT + B-VI

MTC

T1N0M0

0/1

<2.0

26

F7-III2/F

C618R

26

487.6

25.9

2.0/2.5

Reject operation

-

-

 

-

17

F8-II2/F

C618Y

78

1758.0

106.0

3.0/3.5

Reject operation

-

-

 

-

19

F8-III5/M

C618Y

53

<2.0

2.2

−/−

Awaiting surgery

-

-

 

-

19

F8-IV5/F

C618Y

26

5.8

2.0

−/−

TT

CCH

-

NO

<2.0

19

  1. Note: Ct (basal serum Ct): normal <8.4 ng/L for male and <5.0 for female by FACLIA ; CEA (carcinoembryonic antigen): normal ≤ 5.0 ng/ml; Pre-Ct, pre-surgical Ct; Post-Ct, post-surgical Ct; TT, total thyroidectomy; B-VI, bilateral level VI lymph node dissection; R/ L -LND, right/ left lymph neck dissection.
  2. *Tumor size was measured by ultrasonography.