Table 2 Characteristics of symptomatic patients andRET-mutation carriers
Total (n = 33) N (%) | Symptomatic patients (n = 20) N (%) | Mutation carriers (n = 13) N (%) | Pvalue | |
|---|---|---|---|---|
Female patients | 16 (48.5%) | 7(35%) | 9 (69.2%) | |
Genotype | ||||
p.C634F/Y/R | 21 | 12 | 9 | |
p.C 618Y/R | 11 | 7 | 4 | |
p.M 918 T | 1 | 1 | 0 | |
Surgery | ||||
Numbers of patients operated | 26 | 20 | 6 | |
Age at first surgery, mean (years) | 34.6 ± 16.1 | 38.7 ± 13.9 | 20.7 ± 2.9 | <0.001 |
TT with central and lateral LND | 14 | 13 | 1 | |
TT with central LND | 5 | 2 | 3 | |
TT without LND | 2 | 0 | 2 | |
Inappropriate | 5 | 5 | 0 | |
Histology | ||||
Tumor diameter (cm, mean) | 2.2 ± 1.2 | 2.6 ± 1.0 | 0.7 ± 0.4 | 0.007 |
CCH | 1 | 0 | 1 | |
MTC | 25 | 20 | 5 | |
Lymph node metastasis | ||||
N0 | 6 | 1 | 5 | |
N1 | 20 | 19 | 1 | 0.0001 |
Distant metastasis | ||||
M0 | 23 | 18 | 5 | |
M1 | 2 | 2 | 0 | |
Disease-free survival | 6 | 2 | 4 | 0.0001 |