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Table 2 Characteristics of symptomatic patients andRET-mutation carriers

From: Molecular diagnosis and comprehensive treatment of multiple endocrine neoplasia type 2 in Southeastern Chinese

  Total (n = 33) N (%) Symptomatic patients (n = 20) N (%) Mutation carriers (n = 13) N (%) Pvalue
Female patients 16 (48.5%) 7(35%) 9 (69.2%)  
Genotype     
 p.C634F/Y/R 21 12 9  
 p.C 618Y/R 11 7 4  
 p.M 918 T 1 1 0  
Surgery     
Numbers of patients operated 26 20 6  
Age at first surgery, mean (years) 34.6 ± 16.1 38.7 ± 13.9 20.7 ± 2.9 <0.001
TT with central and lateral LND 14 13 1  
TT with central LND 5 2 3  
TT without LND 2 0 2  
Inappropriate 5 5 0  
Histology     
Tumor diameter (cm, mean) 2.2 ± 1.2 2.6 ± 1.0 0.7 ± 0.4 0.007
 CCH 1 0 1  
 MTC 25 20 5  
Lymph node metastasis     
 N0 6 1 5  
 N1 20 19 1 0.0001
Distant metastasis     
 M0 23 18 5  
 M1 2 2 0  
Disease-free survival 6 2 4 0.0001