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Table 2 Literature data regarding gynecological cancer management in Lynch syndrome families

From: Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families

Author

Year

Patients

Methods

Outcome/drawback

References

Ketabi Z

2014

236 women from LS families/8 years

Biennial TVUs/ CA125/ES

1 OC (II B) and 3 interval OCs diagnosed

[23]

Gerritzen LH

2009

100 LS carriers or AMS members/2,5 years

TVUs/CA125/ES

1 OC diagnosed (III C)

[38]

Rijcken FE

2003

41 LS carriers or AMS members/5 years

TVUs/CA125/optional ES

1 interval EC detected

[39]

Dove-Edwin I

2002

269 AMS females/826 person-years

TVUS only

2 cases of EC- neither case detected by surveillance

[40]

Renkonen-Sinisalo L

2007

175 LS carriers/759 person-years

TVUs/CA125/routine ES

4 OC occured, none detected by surveillance

[41]

Stuckless S

2013

174 MSH2 carriers/5 years

TVUs/CA125/ES

3 deaths due to OCs both in screened and unscreened females

[42]

Schmeler KM

2006

315 LS carriers/10 years

Surgery

OC: 0/47 cases bilat salpino-oophorect. (0%) vs 12/223 no surgery (5.5%) EC: 0/61 hysterectomy (0%) vs 69/210 no surgery (33%) Surgical complication rate 1.6 percent, no data regarding overall survival

[43]

Manchandra R

2012

41 women from LS families/8 years

TVUs/routine ES

TVU alone missed 1 EC and 1 premalignant lesion

[56]

  1. TUV – transvaginal ultrasound.
  2. ES – endometrial sampling.