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Table 1 Cancer spectrum in MMR genes mutation positive and negative HNPCC families

From: Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families

  

Mutation positive

    

Mutation negative

  
 

N

Mean age

%

<50

≥50

 

N

Mean age

%

<50

≥50

CRC

289

48,2

50,4 [289/573]

171

118

CRC

345

53,4

58,6 [345/588]

156

189

EC

138

49,8

24,1 [138/573]

69

69

EC

81

51

13,7 [81/588]

41

40

OC

21

42,6

3,66 [21/573]

19

2

OC

18

54,6

3,06 [18/588]

5

13

KI

6

52,2

1,04 [6/573]

3

3

KI

13

57,3

2,21 [13/588]

3

10

BL

5

55,4

0,87 [5/573]

3

2

BL

6

49

1,02 [6/588]

3

3

LC

3

60

0,52 [3/573]

1

2

LC

2

68,5

0,34 [2/588]

0

2

ST

12

52,6

2,09 [12/573]

6

6

ST

9

49,2

1,53 [9/588]

6

3

PC

6

55,2

1,04 [6/573]

2

4

PC

5

56,4

0,85 [5/588]

1

4

Liv

8

47,6

1,39 [8/573]

5

3

Liv

4

60

0,68 [4/588]

1

3

FGT

36

50,7

6,28 [36/573]

17

19

FGT

32

51,4

5,44 [32/588]

14

18

BR

28

52

4,88 [28/573]

9

19

BR

32

51

5,44 [32/588]

16

16

BONES

4

59,2

0,70 [4/573]

1

3

Thr

1

51

0,17 [1/588]

0

1

Gallbladder

1

50

0,17 [1/573]

0

1

SS

1

58

0,17 [1/588]

0

1

CSU

9

51,4

1,57 [9/573]

4

5

CSU

25

52,3

4,25 [25/588]

10

15

SKIN

2

48,5

0,35 [2/573]

1

1

SKIN

2

59,5

0,34 [2/588]

1

1

MM

1

44

0,17 [1/573]

1

0

MM

1

72

0,17 [1/588]

0

1

Lx

1

52

0,17 [1/573]

0

1

OUN

2

35,5

0,34 [2/588]

1

1

OUN

3

42

0,52 [3/573]

2

1

LEUC

6

50,7

1,02 [6/588]

2

4

LEUC

2

63

0,35 [2/573]

0

2

Salivary gland

1

33

0,17 [1/588]

1

0

LYMPH

1

60

0,17 [1/573]

0

1

      
  1. SS-soft tissue sarcoma, CRC-colorectal cancer, EC-endometrial cancer, BL-bladder cancer, KI- kidney cancer, OC- ovarian cancer, LC- lung cancer, ST- stomach cancer, PC- prostate cancer, Liv- liver cancer, FGT- female genital tract, BR- breast cancer, Thr- thyroid cancer, CSU- cancer suspected unknow, MM- malignant melanoma, Lx- larynx cancer, OUN- central nervous system cancer, LEUC- leukemia, LYMPH- lymphoma.