Figure 1
From: Molecular study of the perforin gene in familial hematological malignancies
F1 Family Pedigree. The PRF1 mutation is carried by the proband's healthy mother and was also detected in his healthy brother and healthy son. The proband (Individual IV-2) had HL at the age of 32 years. His cousin (Individual IV-6) had HL at the age of 36 years. Squares stand for male and circles, for female. Open symbols represent unaffected persons, and closed symbols represent affected persons. The asterisk indicates that a germline PRF1 mutation was identified.