Table 3 Cowden syndrome and general population cancer risks
From: Cancer and Lhermitte-Duclos disease are common in Cowden syndrome patients
Site | Literature† | This study: Overall | This study: Cumulative* (95% CI) | General population lifetime risk‡ |
|---|---|---|---|---|
Breast [female] | 25-50% | 45% | 81% (66-90) | 14% |
Lhermitte-Duclos | Not reported | 15% | 32% (19-49) | Very rare |
Thyroid | 3-10% | 12% | 21% (14-29) | 1% |
Endometrium | 5-10% | 9% | 19% (10-32) | 3% |
Colon and rectum | Not reported | 5% | 16% (8-24) | 6% |
Kidney | Not reported | 4% | 19% (10-32) | 1% |