BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia

Table 2 Clinically important mutations in BRCA1 and BRCA2 genes and cancer incidence in relatives from Estonia.

Mutation	Patient ID	Nationality	Age of cancer diagnosis	Breast or ovarian cancer in relatives	Other cancers in relatives
*BRCA1 Gene*
c.3881_3882delGA	fam. 72	Russian	44: BrCa	M:BrCa S:BrCa AU:BrCa	UN:LaCa
c.4154delA	fam. 37	Russian	40: BrCa	GM:OvCa	no
c.4154delA	fam. 13	Estonian	37: BrCa	M:BrCa	no
c.4154delA	fam. 14/A079	Russian	48: OvCa	M:OvCa	no
c.5382insC	early.40	Estonian	36: BrCa	no	no
c.5382insC	early. 49	Russian	39: BrCa	no	no
c.5382insC	early. 59	Russian	30: BrCa	no	GF1, GF2:GaCa, NI1:UtCa, UN:CoCa, NI2: Mel
c.5382insC	fam. 62	Russian	43: BrCa	M:BrCa	GM:GaCa, UN:LuCa
c.5382insC	early. 66	Russian	35: BrCa	no	no
c.5382insC	fam. 77	Russian	38: BrCa	M:OvCa	no
c.5382insC	pred. 49/A062	unknown	ND	S:BrCa, S:BrCa, AU:BrCa	no
*BRCA2 Gene*
c.6631delTTAAATG	fam. 16/A106	unknown	65: OvCa	S: BrCa, AU:OvCa	UN:GaCa, B:PrCa,
c.9610C>T	fam. 03/A065	unknown	36: BrCa	M:BrCa, S:BrCa, NI:BrCa	no

Abbreviations:
fam. Familial cases, early. Early-onset case, pred. Predictive case, ND not diagnosed (predictive testing). M mother, S sister, B brother, GM grandmother, GF grandfather, AU aunt, UN uncle, NI niece. BrCa breast cancer, OvCa ovary cancer, LaCa larynx cancer, GaCa gastric cancer, UtCa uterus cancer, CoCa colon cancer, Mel melanoma, LuCa lung cancer, PrCa prostate.

ISSN: 1897-4287