Table 2 Results of follow-up: Women with cancer before or at first (prevalence) control.
From: High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series
Mutation group | Age group | n | Observation years | Cases with prospective cancer | Mean observation time | Annual incidence rate |
|---|---|---|---|---|---|---|
B1F | <40 | 20 | 78 | 5 | 3.9 | 6.4% |
40-59 | 64 | 299 | 7 | 4.7 | 2.3% | |
60+ | 16 | 55 | 3 | 3.4 | 5.5% | |
SUM | 100 | 432 | 15 | 4.3 | 3.5% | |
B1NF | <40 | 21 | 111 | 2 | 5.3 | 1.8% |
40-59 | 38 | 173 | 3 | 4.6 | 1.7% | |
60+ | 15 | 42 | 4 | 2.8 | 9.5% | |
SUM | 74 | 326 | 9 | 4.4 | 2.8% | |
B2 | <40 | 4 | 19 | 2 | 4.8 | 10.5% |
40-59 | 28 | 119 | 3 | 4.3 | 2.5% | |
60+ | 15 | 47 | 3 | 3.1 | 6.4% | |
SUM | 47 | 185 | 8 | 3.9 | 4.3% | |
ALL | SUM | 221 | 943 | 32 | 4.3 | 3.4% |